Mickiewicz-Góra Dorota, Sznurkowska Katarzyna, Drozd Arleta, Borkowska Anna, Zagierski Maciej, Troch Joanna, Skonieczna-Żydecka Karolina, Szlagatys-Sidorkiewicz Agnieszka
Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Biomedicines. 2024 Apr 18;12(4):897. doi: 10.3390/biomedicines12040897.
Bacteria can impact the host organism through their metabolites, with short-chain fatty acids (SCFAs) being the most important, including acetate (C2), propionate (C3), butyrate (C4), valerate (C5n), and isovalerate (C5i). This study aimed to identify the impact of enteral nutrition on SCFAs in children with cerebral palsy and to test the hypothesis that the type of nutrition in cerebral palsy affects gut SCFA levels. Cerebral palsy is a heterogeneous syndrome resulting from non-progressive damage to the central nervous system. The study group included 30 children diagnosed with cerebral palsy, receiving enteral nutrition (Cerebral Palsy Enteral Nutrition (CPEN)) via gastrostomy. The first reference group (Cerebral Palsy Controls (CPCs)) consisted of 24 children diagnosed with cerebral palsy and fed orally on a regular diet. The second reference group (Healthy Controls (HCs)) consisted of 24 healthy children with no chronic disease and fed on a regular diet. Isolation and measurement of SCFAs were conducted using gas chromatography. Differences were observed in the median contents of isobutyric acid, valeric acid, and isovaleric acid between the CPC group, which had significantly higher levels of those acids than the HC group. No differences were found between the CPEN and CPC groups nor between the CPEN and HC groups. We conclude that enteral nutrition in cerebral palsy has no influence on the levels of SCFAs.
细菌可通过其代谢产物影响宿主生物体，其中短链脂肪酸（SCFAs）最为重要，包括乙酸盐（C2）、丙酸盐（C3）、丁酸盐（C4）、戊酸盐（C5n）和异戊酸盐（C5i）。本研究旨在确定肠内营养对脑瘫患儿SCFAs的影响，并检验脑瘫患儿营养类型影响肠道SCFA水平这一假设。脑瘫是一种由中枢神经系统非进行性损伤导致的异质性综合征。研究组包括30名经胃造口接受肠内营养（脑瘫肠内营养（CPEN））的脑瘫患儿。第一个参照组（脑瘫对照组（CPCs））由24名经诊断患有脑瘫且正常经口饮食的儿童组成。第二个参照组（健康对照组（HCs））由24名无慢性病且正常饮食的健康儿童组成。使用气相色谱法进行SCFAs的分离和测量。在CPC组中观察到异丁酸、戊酸和异戊酸的中位数含量存在差异，该组这些酸的水平显著高于HC组。在CPEN组与CPC组之间以及CPEN组与HC组之间均未发现差异。我们得出结论，脑瘫患儿的肠内营养对SCFAs水平没有影响。
