Falsetti Irene, Palmini Gaia, Donati Simone, Aurilia Cinzia, Iantomasi Teresa, Brandi Maria Luisa
Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy.
Fondazione Italiana Ricerca Sulle Malattie dell'Osso (F.I.R.M.O Onlus), 50129 Florence, Italy.
Biomedicines. 2024 Apr 22;12(4):928. doi: 10.3390/biomedicines12040928.
Menopause, an extremely delicate phase in a woman's life, is characterized by a drop in estrogen levels. This decrease has been associated with the onset of several diseases, including postmenopausal osteoporosis and sarcopenia, which often coexist in the same person, leading to an increased risk of fractures, morbidity, and mortality. To date, there are no approved pharmacological treatments for sarcopenia, while not all of those approved for postmenopausal osteoporosis are beneficial to muscles. In recent years, research has focused on the field of myokines, cytokines, or peptides secreted by skeletal muscle fibers following exercise. Among these, irisin has attracted great interest as it possesses myogenic properties but at the same time exerts anabolic effects on bone and could therefore represent the link between muscle and bone. Therefore, irisin could represent a new therapeutic strategy for the treatment of osteoporosis and also serve as a new biomarker of sarcopenia, thus facilitating diagnosis and pharmacological intervention. The purpose of this review is to provide an updated summary of what we know about the role of irisin in postmenopausal osteoporosis and sarcopenia.
更年期是女性生命中一个极其微妙的阶段，其特征是雌激素水平下降。这种下降与多种疾病的发生有关，包括绝经后骨质疏松症和肌肉减少症，这两种疾病常常共存于同一个人身上，导致骨折、发病和死亡风险增加。迄今为止，尚无获批用于治疗肌肉减少症的药物，而并非所有获批用于治疗绝经后骨质疏松症的药物对肌肉都有益。近年来，研究集中在肌动蛋白领域，即运动后骨骼肌纤维分泌的细胞因子或肽。其中，鸢尾素引起了极大的关注，因为它具有生肌特性，但同时对骨骼发挥合成代谢作用，因此可能代表肌肉与骨骼之间的联系。因此，鸢尾素可能代表一种治疗骨质疏松症的新治疗策略，也可作为肌肉减少症的一种新生物标志物，从而便于诊断和药物干预。本综述的目的是提供关于鸢尾素在绝经后骨质疏松症和肌肉减少症中作用的最新总结。
