Knazicka Zuzana, Bihari Maros, Janco Ivona, Harangozo Lubos, Arvay Julius, Kovacik Anton, Massanyi Peter, Galik Branislav, Saraiva Jorge M A, Habanova Marta
Institute of Nutrition and Genomics, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia.
AgroBioTech Research Center, Slovak University of Agriculture, Trieda Andreja Hlinku 2, 94976 Nitra, Slovakia.
Life (Basel). 2024 Apr 2;14(4):465. doi: 10.3390/life14040465.
Risk elements in blood matrices can affect human health status through associations with biomarkers at multiple levels. The aim of this study was to analyze 15 macro- and microelements in the blood serum of women with overweight (BMI of ≥25 kg/m) and obesity (BMI of ≥30 kg/m) and to examine possible associations with biochemical, liver enzymatic parameters, and markers of oxidative stress. Based on the power calculation, the study involved women (in the postmenopausal stage) with overweight ( = 26) and obesity (n = 22), aged between 50-65 years. Multifrequency bioelectrical impedance analysis was used to measure body composition parameters. Concentrations of elements were determined by inductively coupled plasma optical emission spectrometry, and Hg was measured using cold-vapor atomic absorption spectroscopy. Individuals with obesity, as indicated by a higher BMI, percentage of body fat, and visceral fat area, had elevated serum levels of Ca, Mg, Fe, Al, Sr, Pb, and Hg. Concentrations of Al, Cu, K, Sb, Zn, and Pb significantly affected biochemical and liver function markers in women with overweight or obesity. Elements such as Cu and Al were associated with increased total cholesterol. The correlation analysis between total antioxidant status and Cu, Al, and Ni confirmed associations in both groups. Our findings underscore the importance of addressing excess body weight and obesity in relation to risk elements. The results of the research could be beneficial in identifying potential targets for the treatment or prevention of comorbidities in people with obesity.
血液基质中的风险因素可通过与多个层面的生物标志物关联来影响人类健康状况。本研究的目的是分析超重（BMI≥25kg/m）和肥胖（BMI≥30kg/m）女性血清中的15种常量和微量元素，并研究其与生化指标、肝脏酶参数及氧化应激标志物之间可能存在的关联。根据功效计算，该研究纳入了年龄在50 - 65岁之间的绝经后超重女性（n = 26）和肥胖女性（n = 22）。采用多频生物电阻抗分析来测量身体成分参数。通过电感耦合等离子体发射光谱法测定元素浓度，汞则使用冷蒸气原子吸收光谱法进行测量。BMI、体脂百分比和内脏脂肪面积较高表明存在肥胖的个体，其血清钙、镁、铁、铝、锶、铅和汞水平升高。铝、铜、钾、锑、锌和铅的浓度对超重或肥胖女性的生化指标和肝功能标志物有显著影响。铜和铝等元素与总胆固醇升高有关。两组中总抗氧化状态与铜、铝和镍之间的相关性分析均证实了它们之间的关联。我们的研究结果强调了解决超重和肥胖问题与风险元素之间关系的重要性。该研究结果可能有助于确定肥胖人群治疗或预防合并症的潜在靶点。
