Ritzer Lukas, Harris Alon, Arciero Julia, Siesky Brent, Fry Brendan, Januleviciene Ingrida, Oddone Francesco, Carnevale Carmela, Eckert George, Verticchio Vercellin Alice
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Mathematical Sciences, Indiana University Indianapolis.
J Glaucoma. 2025 Apr 1;34(4):267-274. doi: 10.1097/IJG.0000000000002536. Epub 2025 Jan 16.
The relationship between structural and hemodynamic parameters in patients with primary open angle glaucoma is strongest in the temporal region of the optic nerve.
To investigate the relationship between radial peripapillary capillary (RPC) vessel density (VD) and retinal nerve fiber layer (RNFL) thickness in quadrants and sectors of the optic nerve head (ONH) in patients with and without primary open angle glaucoma (POAG).
In a cross-sectional prospective analysis, 191 subjects (80 early-stage POAG; 111 non-glaucomatous controls) were assessed for RNFL thickness and RPC VD in each quadrant [superior (S), inferior (I), nasal (N) and temporal (T)] and sector [inferior-temporal (IT), temporo-inferior (TI), temporo-superior (TS), superior-temporal (ST), inferior-nasal (IN), naso-inferior (NI), naso-superior (NS), and superior-nasal (SN) sectors] of the ONH through optical coherence tomography angiography (OCTA). Pearson correlations were used to test for associations between measurements, with P<0.05 considered statistically significant.
Significantly stronger positive correlations were found between RPC VD and RNFL thickness in the S, I, and T quadrants in POAG patients compared with non-glaucomatous controls (all P<0.05). The temporal quadrant in POAG patients displayed the largest difference in correlation compared with controls. A stronger positive correlation was also found between RPC VD and RNFL thickness in the temporal sectors of the ONH in POAG patients compared with controls, with the largest difference in the TS sector (all P<0.05).
Early-stage POAG patients have a stronger relationship between RPC VD and RNFL in the temporal regions of the ONH compared with non-glaucomatous controls, with the TS sector demonstrating the largest difference between groups. Temporal sector VD loss may represent an early-stage biomarker for vascular-linked POAG disease.
精准视网膜成像系统（PRCIS）：原发性开角型青光眼患者的结构参数与血流动力学参数之间的关系在视神经颞侧区域最为显著。
研究原发性开角型青光眼（POAG）患者和非POAG患者视神经乳头（ONH）象限及扇区的放射状视乳头周围毛细血管（RPC）血管密度（VD）与视网膜神经纤维层（RNFL）厚度之间的关系。
在一项横断面前瞻性分析中，通过光学相干断层扫描血管造影（OCTA）对191名受试者（80例早期POAG患者；111例非青光眼对照者）的每个象限[上（S）、下（I）、鼻侧（N）和颞侧（T）]以及ONH的扇区[颞下（IT）、下颞（TI）、颞上（TS）、上颞（ST）、鼻下（IN）、下鼻（NI）、鼻上（NS）和上鼻（SN）扇区]的RNFL厚度和RPC VD进行评估。采用Pearson相关性分析来检验测量值之间的关联，P<0.05被认为具有统计学意义。
与非青光眼对照者相比，POAG患者的S、I和T象限中，RPC VD与RNFL厚度之间的正相关性显著更强（均P<0.05）。与对照者相比，POAG患者的颞侧象限在相关性方面显示出最大差异。与对照者相比，POAG患者ONH颞侧扇区的RPC VD与RNFL厚度之间也存在更强的正相关性，TS扇区的差异最大（均P<0.05）。
与非青光眼对照者相比，早期POAG患者ONH颞侧区域的RPC VD与RNFL之间的关系更强，TS扇区显示出两组之间的最大差异。颞侧扇区VD损失可能代表血管相关性POAG疾病的早期生物标志物。
