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麸质敏感患者无结构病理学改变的感觉症状

Sensory Symptoms without Structural Pathology in Patients with Gluten Sensitivity.

作者信息

Hadjivassiliou Marios, Trott Nick, Hoggard Nigel, Sanders David S

机构信息

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield S10 2JF, UK.

Department of Dietetics, Sheffield Teaching Hospitals NHS Trust, Sheffield S10 2JF, UK.

出版信息

Nutrients. 2024 Apr 19;16(8):1209. doi: 10.3390/nu16081209.


DOI:10.3390/nu16081209
PMID:38674899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11053768/
Abstract

UNLABELLED: We report on a group of patients with gluten sensitivity with and without coeliac disease presenting with unexplained sensory symptoms in the absence of structural pathology. METHODS: The patients were selected from the gluten neurology clinic based at the Royal Hallamshire Hospital, Sheffield, UK, on the basis of sensory symptoms but normal neuroaxis imaging and peripheral nerve evaluation. RESULTS: A total of 30 patients were identified with a mean age at presentation of 47 years. The prevalence of enteropathy was 78%. The sensory disturbance was characterised by tingling at 50%, numbness at 27%, pain at 20%, burning at 13% and "buzzing" feeling at 7%. The distribution of the sensory symptoms included hands and feet in 27% of the patients, torso in 27%, legs only in 23%, face in 17% and arms only in 10%. For five patients, the sensory disturbance was migratory and affected different parts of the body at any given time. After the introduction of a gluten-free diet, 77% of patients noted significant improvement in their sensory symptoms. In one-third of the patients, there was a complete resolution of the sensory symptoms. CONCLUSION: Unexplained sensory symptoms can be seen in patients with gluten sensitivity and respond to strict adherence to a gluten-free diet.

摘要

未标注:我们报告了一组麸质敏感性患者,其中有乳糜泻和无乳糜泻的患者,他们在没有结构病理学改变的情况下出现无法解释的感觉症状。 方法:这些患者是从英国谢菲尔德皇家哈勒姆郡医院的麸质神经科诊所挑选出来的,基于感觉症状但神经轴成像和周围神经评估正常。 结果:共确定了30名患者,就诊时的平均年龄为47岁。肠病的患病率为78%。感觉障碍的特征为:刺痛占50%,麻木占27%,疼痛占20%,灼痛占13%,“嗡嗡”感占7%。感觉症状的分布包括:27%的患者累及手和脚,27%累及躯干,23%仅累及腿部,17%累及面部,10%仅累及手臂。有5名患者的感觉障碍是游走性的,在任何给定时间影响身体的不同部位。引入无麸质饮食后,77%的患者感觉症状有显著改善。三分之一的患者感觉症状完全消失。 结论:麸质敏感性患者可出现无法解释的感觉症状,严格坚持无麸质饮食对此有反应。

相似文献

[1]
Sensory Symptoms without Structural Pathology in Patients with Gluten Sensitivity.

Nutrients. 2024-4-19

[2]
Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten-free diet.

Aliment Pharmacol Ther. 2016-9

[3]
Clinical response to gluten withdrawal is not an indicator of coeliac disease.

Scand J Gastroenterol. 2008

[4]
Gluten sensitivity: from gut to brain.

Lancet Neurol. 2010-3

[5]
Motives for adherence to a gluten-free diet: a qualitative investigation involving adults with coeliac disease.

J Hum Nutr Diet. 2014-12

[6]
Compliance with gluten-free diet in children with coeliac disease.

J Pediatr Gastroenterol Nutr. 2008-9

[7]
Diet adherence and gluten exposure in coeliac disease and self-reported non-coeliac gluten sensitivity.

Clin Nutr. 2015-12-10

[8]
Coeliac disease and gastrointestinal symptom screening in adult first-degree relatives.

J Gastroenterol Hepatol. 2017-12

[9]
Celiac Disease and Nonceliac Gluten Sensitivity: A Review.

JAMA. 2017-8-15

[10]
Elevated serum interleukin-2 after gluten correlates with symptoms and is a potential diagnostic biomarker for coeliac disease.

Aliment Pharmacol Ther. 2019-9-4

引用本文的文献

[1]
Shared Immune and Nutrient Metabolism Pathways Between Autism Spectrum Disorder and Celiac Disease: An In Silico Approach.

Nutrients. 2025-4-25

[2]
Paediatric gluten ataxia: a rare neurological presentation of gluten sensitivity in a toddler.

BMJ Case Rep. 2025-2-13

[3]
Non-Celiac Gluten/Wheat Sensitivity-State of the Art: A Five-Year Narrative Review.

Nutrients. 2025-1-8

本文引用的文献

[1]
Sensory nerve action potential in patients with functional neurological disorders with sensory manifestations.

Front Neurol. 2023-10-25

[2]
The Immunobiology and Pathogenesis of Celiac Disease.

Annu Rev Pathol. 2023-1-24

[3]
Celiac disease: a comprehensive current review.

BMC Med. 2019-7-23

[4]
Neurologic Deficits in Patients With Newly Diagnosed Celiac Disease Are Frequent and Linked With Autoimmunity to Transglutaminase 6.

Clin Gastroenterol Hepatol. 2019-12

[5]
Risk of Neuropathy Among 28,232 Patients With Biopsy-Verified Celiac Disease.

JAMA Neurol. 2015-7

[6]
Transglutaminase 6 antibodies in the diagnosis of gluten ataxia.

Neurology. 2013-4-10

[7]
Sensory ganglionopathy due to gluten sensitivity.

Neurology. 2010-9-14

[8]
Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia.

Amino Acids. 2010-3-19

[9]
Gluten sensitivity: from gut to brain.

Lancet Neurol. 2010-3

[10]
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.

Ann Neurol. 2008-9

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