Zhang Shu, Zhang Xiaojuan, Gao Huan, Zhang Xiaoqin, Sun Lidan, Huang Yueyan, Zhang Jie, Ding Baoyue
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 214122, China.
Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China.
Pharmaceutics. 2024 Apr 12;16(4):531. doi: 10.3390/pharmaceutics16040531.
Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, the challenges of inadequate targeting and limited biocompatibility persist. In recent years, cell membrane nano-biomimetic drug delivery systems have emerged as a focal point of research and development, due to their exceptional traits, including precise targeting, low toxicity, and good biocompatibility. This review outlines the categorization and advantages of cell membrane bionic nano-delivery systems, provides an introduction to preparation methods, and assesses their applications in cancer treatment, including chemotherapy, gene therapy, immunotherapy, photodynamic therapy, photothermal therapy, and combination therapy. Notably, the review delves into the challenges in the application of various cell membrane bionic nano-delivery systems and identifies opportunities for future advancement. Embracing cell membrane-coated biomimetic nanoparticles presents a novel and unparalleled avenue for personalized tumor therapy.
基于纳米颗粒的药物递送系统有望通过提高抗肿瘤药物的溶解度和稳定性来治疗癌症。尽管如此，靶向不足和生物相容性有限的挑战仍然存在。近年来，细胞膜纳米仿生药物递送系统因其精准靶向、低毒性和良好生物相容性等优异特性，已成为研发的焦点。本综述概述了细胞膜仿生纳米递送系统的分类和优势，介绍了制备方法，并评估了它们在癌症治疗中的应用，包括化疗、基因治疗、免疫治疗、光动力治疗、光热治疗和联合治疗。值得注意的是，该综述深入探讨了各种细胞膜仿生纳米递送系统应用中的挑战，并确定了未来发展的机会。采用细胞膜包覆的仿生纳米颗粒为个性化肿瘤治疗提供了一条新颖且无与伦比的途径。
