烟酰胺核糖和紫檀芪抑制 UVB 辐射诱导的组织肿胀和免疫抑制。
Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene.
机构信息
Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.
出版信息
Photodermatol Photoimmunol Photomed. 2024 May;40(3):e12961. doi: 10.1111/phpp.12961.
BACKGROUND
Environmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.
OBJECTIVES
To determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid-range ultraviolet radiation.
METHODS
To examine UVB radiation-induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m), and 24-/48-h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4 weeks. Low-dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700 J/m) daily for 4 days, whereas half were mock-irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4 h after the last irradiation, challenged 7 days later on the ears with dinitrofluorobenzene, and 24-h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000 J/m of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3 days later.
RESULTS
Nicotinamide riboside and pterostilbene together inhibited UVB-induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB-induced immune suppression in both the low-dose and high-dose models while nicotinamide riboside alone was more effective in the low-dose model than the high-dose model.
CONCLUSION
Nicotinamide riboside and pterostilbene have protective effects against UVB radiation-induced tissue swelling and immune suppression.
背景
环境紫外线对人类有有害影响，包括晒伤和免疫紊乱。这些免疫变化与皮肤癌的发生有关。
目的
确定全身性给予烟酰胺核苷和/或紫檀芪是否抑制中波紫外线辐射暴露引起的炎症和免疫效应。
方法
为了检查 UVB 辐射诱导的炎症效应，将小鼠喂食标准饲料/水、饲料中的 0.04%紫檀芪和饮用水中的 0.2%烟酰胺核苷、单独喂食烟酰胺核苷的饮食或单独喂食紫檀芪的饮食。4 周后，将小鼠暴露于 UVB 辐射（3500 J/m），并评估 24/48 小时的耳肿胀。我们还询问每种试剂或组合是否抑制两种模型中 UVB 辐射对接触超敏反应的抑制作用。将小鼠喂食标准饮食/水或含 0.08%紫檀芪的饲料、含 0.4%烟酰胺核苷的水或两者 4 周。低剂量：每组中的一半小鼠每天在脱毛的背部接受 UVB 辐射（1700 J/m），连续 4 天，而另一半则进行模拟照射。在最后一次照射后 4 小时，将一半的小鼠在暴露的背部用二硝基氟苯免疫，7 天后在耳朵上用二硝基氟苯进行挑战，并评估 24 小时的耳肿胀。高剂量：小鼠接受类似的治疗，只是给予单次 10000 J/m 的辐射剂量，并且在未照射的剃光腹部上进行免疫接种 3 天后。
结果
烟酰胺核苷和紫檀芪联合使用比单独使用更能抑制 UVB 诱导的皮肤肿胀。紫檀芪单独使用以及两者联合使用可以抑制两种低剂量和高剂量模型中的 UVB 诱导的免疫抑制，而烟酰胺核苷单独使用在低剂量模型中的效果优于高剂量模型。
结论
烟酰胺核苷和紫檀芪对 UVB 辐射诱导的组织肿胀和免疫抑制具有保护作用。
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