Majeed Muhammed, Majeed Shaheen, Jain Renuka, Mundkur Lakshmi, Rajalakshmi H R, Lad Prachi Subhash, Neupane Prakriti
Sami Labs Limited, Bangalore, Karnataka, India.
Sabinsa Corporation, East Windsor, NJ, USA.
Clin Cosmet Investig Dermatol. 2020 Jan 31;13:105-116. doi: 10.2147/CCID.S238358. eCollection 2020.
Both intrinsic and environmental factors play a role in premature ageing of the skin. Natural extracts have been extensively used to reduce the signs of ageing in recent years. Pterostilbene is a natural analog of resveratrol with therapeutic properties against numerous diseases mainly due to its ability to reduce reactive oxygen species.
We studied the anti-aging and skin brightening effect of a 0.4% formulation of natural pterostilbene in healthy volunteers (N=38) in an open-label, single-arm, monocentric study for 8 weeks. The melanogenesis inhibitory, anti-tyrosinase and anti-collagenase and anti-elastase properties of pterostilbene were evaluated in vitro.
Natural pterostilbene showed significant inhibition of melanogenesis in vitro. Pterostilbene cream (0.4%) was highly effective in reducing markers of aging and induces even skin tone. The product was effective in reducing wrinkles and fine lines, improved skin hydration elasticity and showed no adverse effects.
Our results suggest that natural pterostilbene is a safe and effective ingredient for use in cosmetic preparation to reduce the markers of skin ageing and brighten the skin tone.
Clinical Trial Registration India Identifier CTRI/2019/01/017160 [Registered on 18/01/2019].
内在因素和环境因素均在皮肤过早老化中起作用。近年来，天然提取物已被广泛用于减少衰老迹象。紫檀芪是白藜芦醇的天然类似物，主要因其具有减少活性氧的能力而对多种疾病具有治疗特性。
在一项开放标签、单臂、单中心的研究中，我们对38名健康志愿者使用0.4%天然紫檀芪制剂进行了为期8周的抗老化和亮肤效果研究。在体外评估了紫檀芪的抑制黑色素生成、抗酪氨酸酶、抗胶原酶和抗弹性蛋白酶特性。
天然紫檀芪在体外显示出对黑色素生成的显著抑制作用。紫檀芪乳膏（0.4%）在减少衰老标志物和使肤色均匀方面非常有效。该产品在减少皱纹和细纹、改善皮肤水合弹性方面有效，且未显示出不良反应。
我们的结果表明，天然紫檀芪是一种安全有效的成分，可用于化妆品制剂中以减少皮肤衰老标志物并提亮肤色。
临床试验注册印度标识符CTRI/2019/01/017160 [于2019年1月18日注册]
