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作者信息
Van Asbroeck Stephanie, Köhler Sebastian, van Boxtel Martin P J, Lipnicki Darren M, Crawford John D, Castro-Costa Erico, Lima-Costa Maria Fernanda, Blay Sergio Luis, Shifu Xiao, Wang Tao, Yue Ling, Lipton Richard B, Katz Mindy J, Derby Carol A, Guerchet Maëlenn, Preux Pierre-Marie, Mbelesso Pascal, Norton Joanna, Ritchie Karen, Skoog Ingmar, Najar Jenna, Sterner Therese Rydberg, Scarmeas Nikolaos, Yannakoulia Mary, Dardiotis Themis, Rolandi Elena, Davin Annalisa, Rossi Michele, Gureje Oye, Ojagbemi Akin, Bello Toyin, Kim Ki Woong, Han Ji Won, Oh Dae Jong, Trompet Stella, Gussekloo Jacobijn, Riedel-Heller Steffi G, Röhr Susanne, Pabst Alexander, Shahar Suzana, Rivan Nurul Fatin Malek, Singh Devinder Kaur Ajit, Jacobsen Erin, Ganguli Mary, Hughes Tiffany, Haan Mary, Aiello Allison E, Ding Ding, Zhao Qianhua, Xiao Zhenxu, Narazaki Kenji, Chen Tao, Chen Sanmei, Ng Tze Pin, Gwee Xinyi, Gao Qi, Brodaty Henry, Trollor Julian, Kochan Nicole, Lobo Antonio, Santabárbara Javier, Gracia-Garcia Patricia, Sachdev Perminder S, Deckers Kay
机构信息
Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.
Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
出版信息
Alzheimers Dement. 2024 Jun;20(6):3972-3986. doi: 10.1002/alz.13846. Epub 2024 Apr 27.
INTRODUCTION
The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
METHODS
We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.
RESULTS
A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed.
DISCUSSION
Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.
HIGHLIGHTS
A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
引言
大脑健康生活方式（LIBRA）指数基于可改变的生活方式因素得出痴呆风险评分，并已在西方样本中得到验证。我们调查了LIBRA评分与新发痴呆之间的关联是否受地理位置或社会人口学特征的影响。
方法
我们合并了来自六大洲21个前瞻性队列的数据（N = 31,680），并在两步个体参与者数据荟萃分析中进行了特定队列的Cox比例风险回归分析。
结果
LIBRA评分每增加一个标准差，痴呆风险就会增加21%。与欧洲队列相比，亚洲队列以及年龄≤75岁（相对于年龄较大者）的个体之间的关联更强，不过仅在随访的前5年内如此。未观察到与性别、教育程度或社会经济地位的相互作用。
讨论
可改变的风险和保护因素似乎与不同地理和社会人口群体降低痴呆风险相关。
要点
进行了两步个体参与者数据荟萃分析。这是在全球范围内使用来自21个种族 - 地区不同队列的数据完成的。研究了可改变的痴呆风险评分与痴呆之间的关联。该关联因地理区域和基线年龄而有所不同。然而，可改变的痴呆风险和保护因素在所有调查的群体和地区似乎都具有相关性。
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