生活方式对大脑健康风险评分（LIBRA）和遗传易感性与痴呆症和认知能力下降发病的相关性研究。
Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline.
机构信息
Bordeaux Population Health Research Center, INSERM, University of Bordeaux, Bordeaux, France.
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Alzheimers Dement. 2024 Jun;20(6):4250-4259. doi: 10.1002/alz.13801. Epub 2024 May 22.
INTRODUCTION
Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention.
METHODS
We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]).
RESULTS
The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline.
DISCUSSION
Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
简介
评估遗传易感性是否会改变与生活方式相关因素对痴呆症的影响，对于预防至关重要。
方法
我们研究了基线时无痴呆症的 5170 名法国老年人队列参与者，并对其进行了长达 17 年的随访。在基线时构建了包括 12 个可改变因素的生活方式对大脑健康风险评分（LIBRA）（得分越高表示风险越大），并根据对痴呆症的遗传易感性（由载脂蛋白 E [APOE] ε4 等位基因和遗传风险评分 [GRS] 反映）与随后的认知能力下降和痴呆症发病率相关。
结果
LIBRA 与较高的痴呆症发病率相关，但遗传因素没有显著的修饰作用（APOE ε4 非携带者每增加 1 分的风险比为 1.09 [95%置信区间，1.05; 1.13]，携带者为 1.15 [1.08; 1.22]；交互作用的 P 值=0.15）。用 GRS 和认知能力下降也得到了类似的发现。
讨论
无论对痴呆症的遗传易感性如何，基于生活方式的预防可能都是有效的。
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