血液转录组分析揭示了新冠康复期患者体内持续存在的新冠病毒RNA及候选生物标志物。 - Suppr

Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition.

作者信息

Menezes Soraya Maria, Jamoulle Marc, Carletto Maria Paula, Moens Leen, Meyts Isabelle, Maes Piet, Van Weyenbergh Johan

机构信息

Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

HEC Information Sciences, University of Liège, Liège, Belgium.

出版信息

Lancet Microbe. 2024 Aug;5(8):100849. doi: 10.1016/S2666-5247(24)00055-7. Epub 2024 Apr 24.

DOI:10.1016/S2666-5247(24)00055-7

PMID:38677304

Abstract

摘要

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Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition.血液转录组分析揭示了新冠康复期患者体内持续存在的新冠病毒RNA及候选生物标志物。

Lancet Microbe. 2024 Aug;5(8):100849. doi: 10.1016/S2666-5247(24)00055-7. Epub 2024 Apr 24.

Biomarkers and Immune Repertoire Metrics Identified by Peripheral Blood Transcriptomic Sequencing Reveal the Pathogenesis of COVID-19.外周血转录组测序鉴定的生物标志物和免疫反应谱指标揭示了 COVID-19 的发病机制。

Front Immunol. 2021 Aug 24;12:677025. doi: 10.3389/fimmu.2021.677025. eCollection 2021.

Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection.通过 SARS-CoV-2 感染的所有阶段对循环病毒 RNA 进行敏感跟踪。

J Clin Invest. 2021 Apr 1;131(7). doi: 10.1172/JCI146031.

Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning Methods.运用机器学习方法识别新冠病毒特异性转录组生物标志物

Biomed Res Int. 2021 Jul 6;2021:9939134. doi: 10.1155/2021/9939134. eCollection 2021.

Circulating endothelial progenitors are increased in COVID-19 patients and correlate with SARS-CoV-2 RNA in severe cases.循环内皮祖细胞在 COVID-19 患者中增加，并与重症患者的 SARS-CoV-2 RNA 相关。

J Thromb Haemost. 2020 Oct;18(10):2744-2750. doi: 10.1111/jth.15044. Epub 2020 Aug 31.

Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）衍生的小RNA的检测以及与2019冠状病毒病（COVID-19）相关的循环小RNA的变化

Viruses. 2021 Aug 11;13(8):1593. doi: 10.3390/v13081593.

Transcriptome profiling of PBMCs and formalin-fixed autopsy tissues from COVID-19 patients.从 COVID-19 患者的 PBMCs 和福尔马林固定尸检组织中进行转录组谱分析。

STAR Protoc. 2022 Jan 20;3(1):101156. doi: 10.1016/j.xpro.2022.101156. eCollection 2022 Mar 18.

Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion.从尼日利亚队列的血浆样本中检测到低水平的 SARS-CoV-2 RNA：对输血的影响。

PLoS One. 2021 Jun 10;16(6):e0252611. doi: 10.1371/journal.pone.0252611. eCollection 2021.

Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19.COVID-19 患者痊愈后 RT-PCR 结果阳性者病毒载量和抗 SARS-CoV-2 抗体的动态变化。

Korean J Intern Med. 2021 Jan;36(1):11-14. doi: 10.3904/kjim.2020.325. Epub 2020 Nov 25.

Protocol to decode the role of transcriptionally active microbes in SARS-CoV-2-positive patients using an RNA-seq-based approach.使用基于 RNA-seq 的方法解码转录活跃的微生物在 SARS-CoV-2 阳性患者中的作用的方案。

STAR Protoc. 2024 Jun 21;5(2):103071. doi: 10.1016/j.xpro.2024.103071. Epub 2024 May 19.

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Challenges in diagnosis and treatment of long COVID.长期新冠的诊断与治疗挑战

Front Med (Lausanne). 2025 Aug 21;12:1641411. doi: 10.3389/fmed.2025.1641411. eCollection 2025.

Intermittent fasting and a no-sugar diet for Long COVID symptoms: a randomized crossover trial.间歇性禁食和无糖饮食对新冠长期症状的影响：一项随机交叉试验。

Sci Rep. 2025 Jul 29;15(1):27563. doi: 10.1038/s41598-025-07461-0.

Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles.潜在的长期新冠生物标志物：血清细胞外囊泡中SARS-CoV-2相关蛋白的鉴定

Infection. 2025 Jul 21. doi: 10.1007/s15010-025-02612-x.

Droplet Digital PCR or Real-Time PCR as a Method for Quantifying SARS-CoV-2 RNA in Plasma-Is There a Difference?采用数字液滴PCR或实时PCR定量血浆中SARS-CoV-2 RNA的方法——有差异吗？

Viruses. 2025 May 28;17(6):772. doi: 10.3390/v17060772.

Core features and inherent diversity of post-acute infection syndromes.急性感染后综合征的核心特征与内在多样性。

Front Immunol. 2025 Jun 3;16:1509131. doi: 10.3389/fimmu.2025.1509131. eCollection 2025.

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response.对轻度新冠感染后中位随访28个月的新冠康复患者外周血单核细胞进行的全面转录组评估显示，JAK/STAT信号上调且免疫反应持续时间延长。

Front Immunol. 2025 May 30;16:1589589. doi: 10.3389/fimmu.2025.1589589. eCollection 2025.

Symptoms and pathophysiology of post-acute sequelae following COVID-19 (PASC): a cohort study.新型冠状病毒肺炎（COVID-19）后急性后遗症（PASC）的症状与病理生理学：一项队列研究

EBioMedicine. 2025 May 30;117:105792. doi: 10.1016/j.ebiom.2025.105792.

Advances in Therapeutics for Chronic Lung Diseases: From Standard Therapies to Emerging Breakthroughs.慢性肺病治疗进展：从标准疗法到新兴突破

J Clin Med. 2025 Apr 30;14(9):3118. doi: 10.3390/jcm14093118.

Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19.LEF1-AS1与新型冠状病毒肺炎心血管及神经并发症的关联

J Mol Cell Cardiol Plus. 2024 Dec 22;11:100280. doi: 10.1016/j.jmccpl.2024.100280. eCollection 2025 Mar.

Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.胞质核酸感应作为危重症的驱动因素：机制与治疗进展

Signal Transduct Target Ther. 2025 Mar 19;10(1):90. doi: 10.1038/s41392-025-02174-2.

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Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition.

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