School of Dentistry, Pusan National University, Yangsan, Republic of Korea.
Department of Dermatology, College of Medicine, Pusan National University, Busan, Republic of Korea.
J Dtsch Dermatol Ges. 2024 May;22(5):641-652. doi: 10.1111/ddg.15380. Epub 2024 Apr 28.
The association between psoriasis and alcohol consumption has been inconsistent across various studies. However, to the best of our knowledge, no dose-response meta-analysis has been performed to date. This study aims to investigate the association between alcohol consumption and psoriasis. The search was performed on July 27, 2021, using Embase and MEDLINE. The restricted cubic spline analysis was used to perform a dose-response analysis. We identified 3,904 studies, of which 48 studies with 1,702,847 individuals across 24 countries were included. Alcohol consumption was positively associated with psoriasis (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.27-1.70). In addition, a significantly increased OR for psoriasis was observed in males (OR, 1.84; 95% CI, 1.13-3.01) but not in females (OR, 1.22; 95% CI, 0.97-1.54). Based on eight studies, including three cohort and five case-control studies, the analysis revealed that with each additional gram of daily alcohol intake, the OR for psoriasis increased by 4%. We found a positive association between alcohol consumption and psoriasis. The association is more prominent in the group drinking more than 45 g of alcohol per day (3.2 alcoholic drink equivalent).
银屑病与饮酒之间的关联在不同的研究中并不一致。然而，据我们所知，迄今为止尚未进行剂量-反应荟萃分析。本研究旨在探讨饮酒与银屑病之间的关联。搜索于 2021 年 7 月 27 日在 Embase 和 MEDLINE 上进行。采用限制性立方样条分析进行剂量-反应分析。我们共确定了 3904 项研究，其中包括 24 个国家的 48 项研究，共涉及 1702847 人。饮酒与银屑病呈正相关（优势比 [OR]，1.47；95%置信区间 [CI]，1.27-1.70）。此外，在男性中观察到银屑病的 OR 显著增加（OR，1.84；95% CI，1.13-3.01），而在女性中则没有（OR，1.22；95% CI，0.97-1.54）。基于 8 项研究，包括 3 项队列研究和 5 项病例对照研究，分析显示，每日饮酒量每增加 1 克，银屑病的 OR 增加 4%。我们发现饮酒与银屑病之间存在正相关。在每天饮酒超过 45 克（3.2 个酒精饮料当量）的人群中，这种关联更为明显。
