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荆芥（Nepeta cataria L.）精油对犬皮肤感染病原菌的抗菌作用。

Antimicrobial effects of catnip (a L.) essential oil against canine skin infection pathogens.

作者信息

Borlace Glenn Neville, Singh Ranee, Seubsasana Supawadee, Chantaranothai Pranom, Thongkham Eakachai, Aiemsaard Jareerat

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Division of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

Vet World. 2024 Mar;17(3):585-592. doi: 10.14202/vetworld.2024.585-592. Epub 2024 Mar 8.

DOI:10.14202/vetworld.2024.585-592
PMID:38680153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11045539/
Abstract

BACKGROUND AND AIM

Catnip essential oils have antimicrobial effects against bacteria, yeast, and fungi; however, there is limited information regarding their antimicrobial activity against pathogens that cause canine skin infections. This study aimed to identify the phytochemical constituents of catnip essential oil and assay its antimicrobial activity against , , , , , and .

MATERIALS AND METHODS

Catnip essential oil was extracted by hydrodistillation, and its chemical constituents were analyzed by gas chromatography-mass spectrometry (GC-MS). antimicrobial activity was investigated using broth microdilution and time-kill tests. To evaluate the effect of catnip essential oil on microbial morphology and cell membrane integrity, scanning electron microscopy (SEM) and leakage studies were conducted.

RESULTS

GC-MS analysis revealed that the principal components of catnip essential oil were - and -nepetalactone (57.09% of peak area), --nepetalactone (39.69% of peak area), -caryophyllene (1.88% of peak area), and caryophyllene oxide (1.34% of peak area). The minimum inhibitory concentration, minimum bactericidal concentration, and minimum fungicidal concentration values determined by broth microdilution ranged from 0.0625 mg/mL to 4.0 mg/mL. Time-kill testing showed that the germicidal effects of catnip essential oil were time and concentration-dependent, respectively. Environmental SEM and cell leakage analysis indicated that catnip essential oil disrupted the integrity of cell membranes in the tested microorganisms.

CONCLUSION

Catnip essential oil has potential as an alternative antimicrobial against a wide range of canine skin infection pathogens, including , and .

摘要

背景与目的

猫薄荷精油对细菌、酵母和真菌具有抗菌作用；然而，关于其对引起犬类皮肤感染的病原体的抗菌活性的信息有限。本研究旨在鉴定猫薄荷精油的植物化学成分，并测定其对[具体细菌名称1]、[具体细菌名称2]、[具体细菌名称3]、[具体细菌名称4]、[具体细菌名称5]和[具体真菌名称]的抗菌活性。

材料与方法

采用水蒸馏法提取猫薄荷精油，并用气相色谱 - 质谱联用仪（GC - MS）分析其化学成分。使用肉汤微量稀释法和时间杀菌试验研究抗菌活性。为评估猫薄荷精油对微生物形态和细胞膜完整性的影响，进行了扫描电子显微镜（SEM）和渗漏研究。

结果

GC - MS分析表明，猫薄荷精油的主要成分是α - 和β - 荆芥内酯（占峰面积的57.09%）、γ - 荆芥内酯（占峰面积的39.69%）、α - 石竹烯（占峰面积的1.88%）和石竹烯氧化物（占峰面积的1.34%）。通过肉汤微量稀释法测定的最低抑菌浓度、最低杀菌浓度和最低杀真菌浓度值范围为0.0625 mg/mL至4.0 mg/mL。时间杀菌试验表明，猫薄荷精油的杀菌作用分别与时间和浓度有关。环境扫描电子显微镜和细胞渗漏分析表明，猫薄荷精油破坏了受试微生物的细胞膜完整性。

结论

猫薄荷精油有潜力作为一种替代抗菌剂，用于对抗多种犬类皮肤感染病原体，包括[具体细菌名称1]、[具体细菌名称2]、[具体细菌名称3]、[具体细菌名称4]、[具体细菌名称5]和[具体真菌名称]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/e51fa957e262/Vetworld-17-585-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/0e7478581119/Vetworld-17-585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/5d17ab7e044e/Vetworld-17-585-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/dec7c2eb8269/Vetworld-17-585-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/e51fa957e262/Vetworld-17-585-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/0e7478581119/Vetworld-17-585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/5d17ab7e044e/Vetworld-17-585-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/dec7c2eb8269/Vetworld-17-585-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ac/11045539/e51fa957e262/Vetworld-17-585-g004.jpg

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