New Use Agriculture and Natural Plant Products Program, Department of Plant Biology, Rutgers University, New Brunswick, New Jersey, USA.
Department of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California, USA.
Sci Rep. 2019 Feb 6;9(1):1524. doi: 10.1038/s41598-018-36814-1.
There is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates. Natural products are often used when DEET cannot be afforded or accessed and when consumers choose not to use a synthetic repellent. The essential oils from two newly bred Nepeta cataria (catnip) plants representing two different chemotypes and their respective isolated nepetalactone isomers were evaluated as mosquito repellents against Aedes aegypti mosquitoes that transmit the Zika and Dengue virus in a one choice landing rate inhibition assay. A dose response curve was generated for each treatment and a time course analysis of repellency was performed over 24 hours with a N. cataria essential oil sample. The results indicate that all essential oil samples and their respective purified nepetalactone isomers were able to achieve greater than 95% repellency. Between two and four hours, the ability to repel more than 95% of the mosquitoes diminished. At the lowest concentrations tested, the nepetalactones and crude essential oil samples were more effective than DEET at reducing the number of mosquito landings.
人们越来越需要改进和负担得起的驱虫剂来减少高死亡率的快速传播疾病的传播。当无法获得或无法使用避蚊胺，或者消费者选择不使用合成驱虫剂时，通常会使用天然产品。两种新培育的荆芥（猫薄荷）植物的精油代表两种不同的化学型及其各自分离的荆芥内酯异构体被评估为驱蚊剂，以抵抗传播寨卡病毒和登革热病毒的埃及伊蚊，在一个选择降落率抑制测定中。为每种处理生成了剂量反应曲线，并在 24 小时内对驱虫剂进行了时间过程分析，使用了荆芥精油样本。结果表明，所有精油样本及其各自的纯化荆芥内酯异构体都能够达到 95%以上的驱虫效果。在两到四个小时之间，驱除超过 95%的蚊子的能力下降。在测试的最低浓度下，荆芥内酯和粗精油样本比避蚊胺更能有效减少蚊子的降落数量。
