Department of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, Jiangxi, China.
Department of Immunology, International Cancer Center, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, Guangdong, China.
Front Immunol. 2024 Apr 12;15:1381970. doi: 10.3389/fimmu.2024.1381970. eCollection 2024.
Breast cancer is a prominent health issue amongst women around the world. Immunotherapies including tumor targeted antibodies, adoptive T cell therapy, vaccines, and immune checkpoint blockers have rejuvenated the clinical management of breast cancer, but the prognosis of patients remains dismal. Metabolic reprogramming and immune escape are two important mechanisms supporting the progression of breast cancer. The deprivation uptake of nutrients (such as glucose, amino acid, and lipid) by breast cancer cells has a significant impact on tumor growth and microenvironment remodeling. In recent years, in-depth researches on the mechanism of metabolic reprogramming and immune escape have been extensively conducted, and targeting metabolic reprogramming has been proposed as a new therapeutic strategy for breast cancer. This article reviews the abnormal metabolism of breast cancer cells and its impact on the anti-tumor activity of T cells, and further explores the possibility of targeting metabolism as a therapeutic strategy for breast cancer.
乳腺癌是全球女性面临的一个重要健康问题。免疫疗法包括肿瘤靶向抗体、过继性 T 细胞疗法、疫苗和免疫检查点抑制剂，已经使乳腺癌的临床治疗得到了复兴，但患者的预后仍然不容乐观。代谢重编程和免疫逃逸是支持乳腺癌进展的两个重要机制。乳腺癌细胞对营养物质（如葡萄糖、氨基酸和脂质）的剥夺摄取对肿瘤生长和微环境重塑有重大影响。近年来，对代谢重编程和免疫逃逸机制的深入研究已经广泛开展，靶向代谢重编程被提出作为乳腺癌的一种新的治疗策略。本文综述了乳腺癌细胞的异常代谢及其对 T 细胞抗肿瘤活性的影响，并进一步探讨了将代谢作为一种治疗策略用于乳腺癌的可能性。
