Geriatric Unit, Neuromotor Department, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Clinical Laboratory, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Int J Mol Sci. 2023 Oct 19;24(20):15369. doi: 10.3390/ijms242015369.
Lactate represents the main product of pyruvate reduction catalyzed by the lactic dehydrogenase family of enzymes. Cancer cells utilize great quantities of glucose, shifting toward a glycolytic metabolism. With the contribution of tumor stromal cells and under hypoxic conditions, this leads toward the acidification of the extracellular matrix. The ability to shift between different metabolic pathways is a characteristic of breast cancer cells and is associated with an aggressive phenotype. Furthermore, the preliminary scientific evidence concerning the levels of circulating lactate in breast cancer points toward a correlation between hyperlactacidemia and poor prognosis, even though no clear linkage has been demonstrated. Overall, lactate may represent a promising metabolic target that needs to be investigated in breast cancer.
乳酸代表丙酮酸还原的主要产物，由乳酸脱氢酶家族的酶催化。癌细胞大量利用葡萄糖，转向糖酵解代谢。在肿瘤基质细胞的贡献下，并在缺氧条件下，这导致细胞外基质的酸化。在不同代谢途径之间转换的能力是乳腺癌细胞的一个特征，并与侵袭性表型相关。此外，关于循环乳酸水平在乳腺癌中的初步科学证据表明，高乳酸血症与预后不良之间存在相关性，尽管尚未证明明确的联系。总的来说，乳酸可能代表一个有前途的代谢靶点，需要在乳腺癌中进行研究。
