Wen Dan, Cao Song, Feng Yonghuai
Department of Hematology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi China.
Ibrain. 2023 Sep 6;9(4):421-430. doi: 10.1002/ibra.12132. eCollection 2023 Winter.
The incidence of multiple myeloma (MM) is increasing year by year, requiring chemotherapy drugs to control the condition. With the advent of new proteasome inhibitors, immunomodulators, and monoclonal antibodies, the prognosis of patients has improved significantly. However, peripheral neuropathy caused by drugs limits the dose and duration of treatment, which seriously affects patients' quality of life and treatment outcome. Although the neuropathies induced by chemotherapy drugs have attracted much attention, their mechanism and effective prevention and treatment measures are not clear. Therefore, how to alleviate peripheral neuropathy caused by drugs for treatment of MM is a key issue in improving patients' quality of life and prolonging their survival time, which have some clinical value. In this paper, we review the current research on the pathogenesis, pharmacological and nonpharmacological treatment, and prevention, which expects to present instruction for peripheral neuropathy after treatment of MM.
多发性骨髓瘤（MM）的发病率逐年上升，需要化疗药物来控制病情。随着新型蛋白酶体抑制剂、免疫调节剂和单克隆抗体的出现，患者的预后有了显著改善。然而，药物引起的周围神经病变限制了治疗的剂量和疗程，严重影响患者的生活质量和治疗效果。尽管化疗药物引起的神经病变已引起广泛关注，但其机制以及有效的预防和治疗措施尚不清楚。因此，如何减轻治疗MM药物引起的周围神经病变是提高患者生活质量和延长生存时间的关键问题，具有一定的临床价值。本文综述了目前关于其发病机制、药物和非药物治疗及预防的研究，以期为MM治疗后周围神经病变提供指导。
