Medicana International Hospital, Urology Clinic, Canik/Samsun Türkiye. Atilim University, Yenimahalle, Şht. Mesut Birinci Cd. No:85, 55080, Ankara, Türkiye.
Atılım University, Faculty of Medicine, Ankara, Türkiye.
Int Urol Nephrol. 2024 Sep;56(9):2869-2876. doi: 10.1007/s11255-024-04057-x. Epub 2024 Apr 30.
Many factors influence male sexual function, including metabolic disorders such as metabolic syndrome (MetS). We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on male sexual function.
A total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded. Sex-specific VAI was calculated using the [(WC/39.68) + (1.88xMI)] × (TG/1.03) × (1.31/HDL) formula and using Ln (fasting triglycerides) × (fasting glucose)/2] formula, TyG index was calculated. Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire and male sexual health questionnaire (MSHQ) were used for erectile function and ejaculatory function, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk.
A higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI showed similar predictive abilities for ED. Patients with MetS had worse ejaculation quality compared to those without MetS.
These findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help to mitigate their negative impact on male sexual function.
许多因素会影响男性的性功能，包括代谢紊乱，如代谢综合征（MetS）。我们旨在研究两种代谢指标，甘油三酯-葡萄糖（TyG）指数和内脏脂肪指数（VAI），对男性性功能的影响。
共纳入 400 名患有性功能障碍的男性。记录人体测量学数据和合并症。记录血清总睾酮、催乳素和雌二醇水平。使用 [(WC/39.68) + (1.88xMI)] × (TG/1.03) × (1.31/HDL)公式和使用 Ln (空腹甘油三酯) × (空腹血糖)/2]公式计算特定性别的 VAI。使用土耳其验证的国际勃起功能指数 (IIEF) 问卷 15 项长表和男性性健康问卷 (MSHQ) 分别评估勃起功能和射精功能。ROC 分析用于评估 TyG 和 VAI 截断值预测 ED 风险的能力。
较高的 TyG 指数和 VAI 与 ED 风险增加相关。MetS 的存在进一步恶化了性功能，性满意度、 orgasm、欲望和总体满意度评分较低。TyG 指数和 VAI 对 ED 具有相似的预测能力。与无 MetS 的患者相比，MetS 患者的射精质量更差。
这些发现强调了 TyG 指数和 VAI 作为预测和评估男性性功能障碍的便捷工具的潜力，特别是在代谢紊乱的情况下。早期检测和干预代谢综合征和胰岛素抵抗可能有助于减轻其对男性性功能的负面影响。
