Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, No. 16766 Jingshi Road, Jinan, Shandong Province, China.
J Cancer Res Ther. 2024 Apr 1;20(2):531-539. doi: 10.4103/jcrt.jcrt_2484_23. Epub 2024 Apr 30.
This literature explores the immunostimulatory effects of thermal ablation in the tumor microenvironment, elucidating the mechanisms such as immunogenic cell death, tumor-specific antigens, and damage-associated molecular patterns. Furthermore, it outlines critical issues associated with thermal ablation-induced immunostimulatory challenges and offers insights into future research avenues and potential therapeutic strategies.
本文献探讨了热消融在肿瘤微环境中的免疫刺激效应，阐明了免疫原性细胞死亡、肿瘤特异性抗原和损伤相关分子模式等机制。此外，它还概述了与热消融诱导的免疫刺激挑战相关的关键问题，并为未来的研究途径和潜在的治疗策略提供了思路。
