Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Department of Pathology, Hospital Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia.
BMJ Case Rep. 2024 Apr 30;17(4):e259761. doi: 10.1136/bcr-2024-259761.
Catheter-related bloodstream infection (CRBSI) is one of the common healthcare-acquired infections imposing a high burden of morbidity and mortality on the patients. Non-tuberculous mycobacterium is a rare aetiology for CRBSI and poses challenges in laboratory diagnosis and clinical management. This is a case of a woman in her early 60s with underlying end-stage renal failure, diabetes mellitus and hypertension presented with a 2-week history of high-grade fever postregular haemodialysis, vomiting, lethargy and altered mental status.Blood cultures from a permanent catheter and peripheral taken concurrently yielded , identified by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, which established the diagnosis of CRBSI atypically presented with concurrent acute intracranial bleeding and cerebrovascular infarction at initial presentation. She was started on a combination of oral azithromycin, oral amikacin and intravenous imipenem, and the permanent catheter was removed. Despite the treatments instituted, she developed septicaemia, acute myocardial infarction and macrophage activation-like syndrome, causing the patient's death.
导管相关血流感染(CRBSI)是常见的医院获得性感染之一,给患者带来了严重的发病率和死亡率负担。非结核分枝杆菌是 CRBSI 的罕见病因,给实验室诊断和临床管理带来挑战。这是一位 60 岁出头的女性,患有终末期肾衰竭、糖尿病和高血压,在定期血液透析后出现了 2 周的高热、呕吐、乏力和意识改变。从永久性导管和外周血同时采集的血培养物中培养出 ,通过基质辅助激光解吸/电离飞行时间质谱鉴定,明确了 CRBSI 的诊断,其表现不典型,最初表现为并发急性颅内出血和脑血管梗死。她开始接受口服阿奇霉素、口服阿米卡星和静脉注射亚胺培南的联合治疗,并拔除了永久性导管。尽管进行了治疗,她还是出现了败血症、急性心肌梗死和巨噬细胞活化样综合征,导致患者死亡。