脑脊液系统进化的意义。

Ann R Coll Surg Engl. 1979 Sep;61(5):349-56.

A study of the comparative morphology of the cerebrospinal fluid (CSF) system has been made in amphioxus, lamprey, dogfish, goldfish, lungfish, frog, salamander, turtle, pigeon, and mouse. Using mainly intracardiac fixation and a careful histological technique, serial sections have been obtained of the brain in situ surrounded by its various membranes and the skull. The ventricular system, the roof of the hindbrain, the meninges and subarachnoid space, the ependyma with its various derivatives, including the choroid plexuses and paraphysis, and the relationship between the various CSF compartments and the cerebrovascular system have all been compared in these animals. The hypothesis has been derived that the CSF system is primarily developed to maintain the chemical environment necessary to the function of the cells of the central nervous system, including the neuroendocrine pathways.

对文昌鱼、七鳃鳗、角鲨、金鱼、肺鱼、青蛙、蝾螈、乌龟、鸽子和小鼠的脑脊液（CSF）系统进行了比较形态学研究。主要采用心内固定和精细的组织学技术，获取了原位大脑及其各种膜和颅骨周围的连续切片。在这些动物中，对脑室系统、后脑顶、脑膜和蛛网膜下腔、具有各种衍生物（包括脉络丛和松果体旁突）的室管膜，以及各种脑脊液腔室与脑血管系统之间的关系进行了比较。由此得出的假设是，脑脊液系统主要是为维持中枢神经系统细胞功能（包括神经内分泌途径）所需的化学环境而发育的。