Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom.
Front Endocrinol (Lausanne). 2024 Apr 16;15:1357664. doi: 10.3389/fendo.2024.1357664. eCollection 2024.
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, affecting 25-30% of the general population globally. The condition is even more prevalent in individuals with obesity and is frequently linked to the metabolic syndrome. Given the known associations between the metabolic syndrome and common mental health issues, it is likely that such a relationship also exists between NAFLD and mental health problems. However, studies in this field remain limited. Accordingly, the aim of this systematic review and meta-analysis was to explore the prevalence of one or more common mental health conditions (i.e., depression, anxiety, and/or stress) in adults with NAFLD.
PubMed, EBSCOhost, ProQuest, Ovid, Web of Science, and Scopus were searched in order to identify studies reporting the prevalence of depression, anxiety, and/or stress among adults with NAFLD. A random-effects model was utilized to calculate the pooled prevalence and confidence intervals for depression, anxiety and stress.
In total, 31 studies were eligible for inclusion, involving 2,126,593 adults with NAFLD. Meta-analyses yielded a pooled prevalence of 26.3% (95% CI: 19.2 to 34) for depression, 37.2% (95% CI: 21.6 to 54.3%) for anxiety, and 51.4% (95% CI: 5.5 to 95.8%) for stress among adults with NAFLD.
The present findings suggest a high prevalence of mental health morbidity among adults with NAFLD. Given the related public health impact, this finding should prompt further research to investigate such associations and elucidate potential associations between NAFLD and mental health morbidity, exploring potential shared underlying pathophysiologic mechanisms.
https://www.crd.york.ac.uk/prospero/, identifier CRD42021288934.
非酒精性脂肪性肝病（NAFLD）是一种常见的慢性肝病，影响全球 25-30%的一般人群。在肥胖人群中，这种情况更为普遍，并且经常与代谢综合征有关。鉴于代谢综合征与常见心理健康问题之间的已知关联，NAFLD 与心理健康问题之间也可能存在这种关系。然而，该领域的研究仍然有限。因此，本系统评价和荟萃分析的目的是探讨患有 NAFLD 的成年人中一种或多种常见心理健康状况（即抑郁、焦虑和/或压力）的患病率。
为了确定报告 NAFLD 成年人中抑郁、焦虑和/或压力患病率的研究，检索了 PubMed、EBSCOhost、ProQuest、Ovid、Web of Science 和 Scopus。使用随机效应模型计算抑郁、焦虑和压力的汇总患病率和置信区间。
共有 31 项研究符合纳入标准，涉及 2126593 名患有 NAFLD 的成年人。荟萃分析得出，NAFLD 成年人的抑郁患病率为 26.3%（95%CI：19.2-34），焦虑患病率为 37.2%（95%CI：21.6-54.3%），压力患病率为 51.4%（95%CI：5.5-95.8%）。
本研究结果表明，NAFLD 成年人中存在较高的心理健康发病率。鉴于其相关的公共卫生影响，这一发现应该促使进一步研究调查这些关联，并阐明 NAFLD 与心理健康发病率之间的潜在关联，探索潜在的共同潜在病理生理机制。
https://www.crd.york.ac.uk/prospero/，标识符 CRD42021288934。
