Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
F1000Res. 2023 Sep 27;12:1228. doi: 10.12688/f1000research.140173.1. eCollection 2023.
Periodontitis is the chronic inflammation of tooth-supporting tissues that leads to loss of tooth support if untreated. Conventional therapy for periodontitis (mechanical removal of microbial biofilm and oral hygiene enforcement) is augmented by anti-microbial and anti-inflammatory drugs. These drugs are frequently delivered locally into the periodontal pocket for maximum efficiency and minimum adverse effects. The potential of oleogels for periodontal drug delivery has been discussed and further, the future scope of oleogel-based drug delivery systems in dentistry. An oleogel-based local drug delivery system offers several advantages over other systems. Superior mechanical properties (firmness and compressibility), muco-adhesion, shear thinning, thixotropy, controlled drug release and the ability to incorporate water-insoluble drugs clearly distinguish and highlight the potential of oleogels as periodontal local drug delivery systems. Bigels can combine the qualities of both hydrogels and oleogels to provide a more promising option for drug delivery. However, there is limited evidence concerning oleogels as local drug delivery agents in periodontics. Further studies are needed to discern the clinical efficacy of oleogel-based drug delivery systems.
牙周炎是一种慢性的牙齿支持组织炎症，如果不治疗，会导致牙齿支持组织的丧失。牙周炎的常规治疗方法（微生物生物膜的机械去除和口腔卫生措施）通过抗菌和抗炎药物得到了增强。这些药物经常被局部递送到牙周袋中，以达到最大的效率和最小的副作用。已经讨论了油凝胶在牙周病药物传递中的潜力，并且进一步讨论了基于油凝胶的药物传递系统在牙科中的未来范围。基于油凝胶的局部药物传递系统相对于其他系统具有几个优点。优越的机械性能（硬度和可压缩性）、粘膜粘附性、剪切稀化、触变性、控制药物释放以及能够包含水不溶性药物的能力，清楚地区分并突出了油凝胶作为牙周局部药物传递系统的潜力。大凝胶可以结合水凝胶和油凝胶的特性，为药物传递提供更有前途的选择。然而，关于油凝胶作为牙周病局部药物传递剂的证据有限。需要进一步的研究来辨别基于油凝胶的药物传递系统的临床疗效。
