Division of urology, University of Central Florida College of Medicine, Orlando, FL, USA.
Expert Opin Investig Drugs. 2024 Jun;33(6):601-612. doi: 10.1080/13543784.2024.2349285. Epub 2024 May 9.
Overactive bladder syndrome is a common chronic condition with a significant impact on quality of life and economic burden. Persistence with pharmacologic therapy has been limited by efficacy and side effects. A greater understanding of the pathophysiology of overactive bladder has led to the initial evaluation of several drugs affecting ion channels, the autonomic nervous system, and enzymes which may provide useful alternatives for the management of overactive bladder.
A comprehensive review was performed using PubMed and Cochrane databases as well as reviewing clinical trials in the United States. The current standard of care for overactive bladder will be discussed, but this paper focuses on investigational drugs currently in preclinical studies and phase I and II clinical trials.
Current therapies for overactive bladder have limitations in efficacy and side effects. A greater understanding of the pathophysiology of overactive bladder has identified the role(s) of other pathways in the overactive bladder syndrome. Targeting alternative pathways including ion channels and enzymes may provide alternative therapies of overactive bladder and a more tailored approach to the management of overactive bladder.
膀胱过度活动症是一种常见的慢性疾病，对生活质量和经济负担有重大影响。药物治疗的疗效和副作用限制了其持续应用。对膀胱过度活动症病理生理学的深入了解，导致了几种影响离子通道、自主神经系统和酶的药物的初步评估，这些药物可能为膀胱过度活动症的治疗提供有用的选择。
使用 PubMed 和 Cochrane 数据库以及在美国进行的临床试验进行了全面的综述。将讨论膀胱过度活动症的当前标准治疗方法，但本文重点介绍目前处于临床前研究和 I 期和 II 期临床试验阶段的研究性药物。
目前膀胱过度活动症的治疗方法在疗效和副作用方面存在局限性。对膀胱过度活动症病理生理学的深入了解，确定了其他途径在膀胱过度活动症中的作用。针对包括离子通道和酶在内的其他途径可能为膀胱过度活动症提供替代疗法，并为膀胱过度活动症的治疗提供更具针对性的方法。
