微生物细胞外囊泡有助于抗生素耐药性的产生。
Microbial extracellular vesicles contribute to antimicrobial resistance.
机构信息
The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China.
Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
出版信息
PLoS Pathog. 2024 May 2;20(5):e1012143. doi: 10.1371/journal.ppat.1012143. eCollection 2024 May.
With the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to antimicrobial resistance. Therefore, comprehensively elucidating the roles and mechanisms of microbial EVs in conferring resistance could provide new perspectives and avenues for novel antimicrobial approaches. In this review, we systematically examine current research on antimicrobial resistance involving bacterial, fungal, and parasitic EVs, delineating the mechanisms whereby microbial EVs promote resistance. Finally, we discuss the application of bacterial EVs in antimicrobial therapy.
随着全球抗菌药物耐药性危机的不断加剧，我们迫切需要创新策略来对抗耐药微生物。越来越多的证据表明，微生物细胞外囊泡（EVs）对抗菌药物耐药性的产生有一定影响。因此，全面阐明微生物 EVs 赋予耐药性的作用和机制，可以为新型抗菌方法提供新的视角和途径。在这篇综述中，我们系统地研究了涉及细菌、真菌和寄生虫 EVs 的抗菌药物耐药性的当前研究，阐述了微生物 EVs 促进耐药性的机制。最后，我们讨论了细菌 EVs 在抗菌治疗中的应用。
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