German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Department of Neuroradiology, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Berlin, Germany.
PLoS One. 2024 May 2;19(5):e0299939. doi: 10.1371/journal.pone.0299939. eCollection 2024.
Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.
This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.
We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds.
Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks.
We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity.
German Clinical Trials Register (DRKS00007966, 04/05/2015).
参与多模态休闲活动，如演奏乐器，可能对老年人的大脑衰老和痴呆有保护作用。潜在的与音乐活动相关的神经保护相关性尚不清楚。
本横断面研究调查了一生中音乐活动与三个高级脑网络（默认模式、额顶叶和突显网络）的静息态功能连接（RSFC）之间的关联。
我们评估了来自 DZNE 纵向认知障碍和痴呆研究（DELCODE）研究基线队列的 130 名认知未受损的参与者（≥60 岁）。一生中的音乐活动通过使用生活经历问卷（LEQ）报告在早期、中期和晚期生命阶段参与乐器演奏来操作化。报告在所有生命阶段都有音乐活动的参与者（n=65）与在人口统计学和储备特征（包括教育、智力、社会经济地位、自我报告的身体活动、年龄和性别）上匹配的对照组（n=65）进行比较，对照组从未演奏过乐器。使用预先指定的网络种子，在局部（种子到体素）和全局（网络内和网络间）RSFC 模式中比较了两组之间的静息态功能连接。
与匹配的对照组相比，一生中具有音乐活动的老年参与者表现出内侧前额叶皮层（默认模式网络种子）与颞部和额部区域之间的局部 RSFC 显著增加，包括右侧颞极和右侧中央前回延伸到额上回。在三个网络内或网络间的全局 RSFC 中，两组之间没有显著差异。
我们表明，一生中演奏乐器与内侧前额叶皮层与参与高级认知和运动过程的远距离脑区之间的 RSFC 更高有关。保留或增强的功能连接可能有助于具有音乐活动史的老年人大脑健康和适应能力更好。
德国临床试验注册处（DRKS00007966，2015 年 4 月 5 日）。
