Division of Dermatology, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO, USA.
Division of Dermatology, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO, USA.
Trends Immunol. 2024 May;45(5):381-396. doi: 10.1016/j.it.2024.03.005. Epub 2024 May 1.
Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary research field.
最近的研究揭示了感觉神经元在影响哺乳动物宿主免疫方面的新作用，这挑战了神经系统和免疫系统作为独立实体的传统观念。在这篇综述中，我们深入探讨了神经免疫学的这一开创性范例，并讨论了最近的科学证据，这些证据表明感觉神经元对宿主对各种病原体和疾病（包括微生物感染和癌症）的反应产生影响。这些有价值的见解增强了我们对神经系统和免疫系统之间相互作用的理解，也为开发针对免疫介导疾病的创新性候选治疗干预措施铺平了道路，突出了这一跨学科研究领域的重要性。
