Martel Matos Andre A, Scheff Nicole N
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Trends Cancer. 2025 Apr;11(4):309-320. doi: 10.1016/j.trecan.2025.01.003. Epub 2025 Jan 30.
Sensory nerves form a crucial component of the tumor microenvironment (TME) that relays vital information to the central nervous system and modulates tumor progression via immunosurveillance. Afferent activity processed by the brain can sensitize brain circuitry and influence host behaviors. Peripheral sensory signaling (e.g., release of neuropeptides in the TME) can drive phenotypic changes in the tumor immune response, such as increased exhaustion markers and inhibited effector cell activity, which promote cancer progression. In this review we highlight the most recent evidence demonstrating the pivotal role of the sensory nervous system in cancer, with a focus on primary tumor pain, and we discuss the extent to which pain can influence cancer progression and treatment response, including immunotherapeutic strategies.
感觉神经是肿瘤微环境（TME）的关键组成部分，它将重要信息传递给中枢神经系统，并通过免疫监视调节肿瘤进展。大脑处理的传入活动可使脑回路敏感并影响宿主行为。外周感觉信号传导（例如，肿瘤微环境中神经肽的释放）可驱动肿瘤免疫反应的表型变化，如耗竭标志物增加和效应细胞活性受抑制，从而促进癌症进展。在本综述中，我们重点介绍了证明感觉神经系统在癌症中关键作用的最新证据，尤其关注原发性肿瘤疼痛，并讨论了疼痛在多大程度上会影响癌症进展和治疗反应，包括免疫治疗策略。
