Li Lan, Zhou Xin, Liu Wene, Chen Zhen, Xiao Xiaoqin, Deng Guiming
School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China.
The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province, China.
Biochem Biophys Rep. 2024 Apr 23;38:101715. doi: 10.1016/j.bbrep.2024.101715. eCollection 2024 Jul.
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in many pathophysiological processes. Supplementation with NAD and its precursors has been demonstrated as an emerging therapeutic strategy for the diseases. NAD also plays an important role in the reproductive system. Here, we summarize the function of NAD in various reproductive diseases and review the application of NAD and its precursors in the preservation of reproductive capacity and the prevention of embryonic malformations. It is shown that NAD shows good promise as a therapeutic approach for saving reproductive capacity.
烟酰胺腺嘌呤二核苷酸(NAD)是一种参与许多病理生理过程的必需辅酶。补充NAD及其前体已被证明是一种针对这些疾病的新兴治疗策略。NAD在生殖系统中也起着重要作用。在此,我们总结了NAD在各种生殖疾病中的功能,并综述了NAD及其前体在保护生殖能力和预防胚胎畸形方面的应用。结果表明,NAD作为一种挽救生殖能力的治疗方法具有良好的前景。