Golestani Parisa
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Heliyon. 2024 Apr 19;10(9):e29898. doi: 10.1016/j.heliyon.2024.e29898. eCollection 2024 May 15.
The prevalence of skin disorders, especially cancer, is increasing worldwide. Several factors are involved in causing skin cancer, but ultraviolet (UV) light, including sunlight and tanning beds, are considered the leading cause. Different methods such as chemotherapy, radiotherapy, cryotherapy, and photodynamic therapy are mostly used for the skin cancer treatment. However, drug resistance and toxicity against cancer cells are related to these treatments. Lipid-nanoparticles have attracted significant interest as delivery systems due to non-invasive and targeted delivery based on the type of active drug. However, the stratum corneum, the outer layer of the skin, is inherently impervious to drugs. Due to their ability to penetrate the deep layers of the skin, skin delivery systems are capable of delivering drugs to target cells in a protected manner. The aim of this review was to examine the properties and applications of nanoliposomes used in the treatment and prevention of numerous types of skin cancer.
皮肤疾病，尤其是癌症的患病率在全球范围内呈上升趋势。导致皮肤癌的因素有多种，但紫外线（UV），包括阳光和日光浴床，被认为是主要原因。化疗、放疗、冷冻疗法和光动力疗法等不同方法大多用于皮肤癌治疗。然而，这些治疗与癌细胞的耐药性和毒性有关。脂质纳米颗粒作为给药系统因其基于活性药物类型的非侵入性和靶向给药而引起了极大关注。然而，皮肤的外层角质层天然对药物具有不透性。由于其能够穿透皮肤深层，皮肤给药系统能够以受保护的方式将药物递送至靶细胞。本综述的目的是研究用于治疗和预防多种类型皮肤癌的纳米脂质体的特性和应用。
