Chauhan Neha, Vasava Parul, Khan Sharuk L, Siddiqui Falak A, Islam Fahadul, Chopra Hitesh, Emran Talha Bin
Laxminarayan Dev College of Pharmacy, Gujarat Technological University, Bharuch, Gujarat, India.
MUP's College of Pharmacy (B Pharm), Degaon, Risod, Washim, Maharashtra, 444504, India.
Ann Med Surg (Lond). 2022 Sep 8;82:104595. doi: 10.1016/j.amsu.2022.104595. eCollection 2022 Oct.
Ethosomal systems are newer lipid vesicular carriers that have been around for 20 years, but over that period they have grown significantly as a means of transdermal drug delivery. They have a sizable amount of ethanol in them. These nanocarriers carry medicinal substances with various physicochemical qualities throughout the skin and deep skin layers. Since they were created in 1996, ethosomes have undergone substantial investigation; new substances have been added to their original composition, creating new varieties of ethosomal systems. These innovative carriers, which can be added to gels, patches, and lotions, are prepared using several novel methods. In addition to clinical trials, many in vivo models are employed to assess the effectiveness of dermal/transdermal administration. This review focuses on different generation of ethosomes and their comparison with other conventional liposomes.
醇质体系统是较新的脂质囊泡载体，已经存在了20年，但在这段时间里，它们作为一种透皮给药方式有了显著发展。它们含有相当数量的乙醇。这些纳米载体可携带具有各种物理化学性质的药物穿过皮肤和真皮深层。自1996年醇质体被发明以来，已经进行了大量研究；新物质被添加到其原始成分中，创造出了醇质体系统的新品种。这些创新载体可添加到凝胶、贴片和乳液中，通过几种新颖的方法制备。除了临床试验外，许多体内模型也被用于评估皮肤/透皮给药的有效性。本综述重点关注不同代醇质体及其与其他传统脂质体的比较。
