Che Guozhu, Liu Ying, Zhang Na, Zhao Jing
Shanxi Bethune Hospital, Department of Rheumatology and Immunology, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyu, China.
J Med Biochem. 2024 Apr 23;43(2):243-249. doi: 10.5937/jomb0-45932.
To assess the influence of serum level of YAP on laboratory examination findings, imaging findings and disease activity of rheumatoid arthritis patients combined cardiovascular disease (RA-CVD).
RA-CVD patients (n=60), RA-nCVD patients (n=60) and healthy subjects (n=60) were recruited. Serum levels of YAP in them were detected by qRT-PCR. Their baseline characteristics were analyzed and compared. Disease activity, CVD risk factors and imaging findings in RA-CVD and RA-nCVD patients were evaluated and compared. In addition, potential influences of YAP on disease activity, CVD risk factors and imaging findings in RA-CVD patients were assessed.
RA-CVD patients had higher levels of ERS, anti-CCP, RF, HDL-C, CRP, FRS, BNP, LA, LVs, LVd and cIMT, and lower level of EF in comparison to RA-nCVD patients. Serum level of YAP was higher in RA-CVD patients than that of RA-nCVD patients and healthy subjects. YAP level was positively correlated to DAS28, TG, CRP, PLT, FRS, BNP and cIMT in RA-CVD patients.
Serum level of YAP increases in RA-CVD patients. YAP is a potential factor driving the development of CVD in RA patients through regulating inflammatory response, lipid metabolism, glycometabolism and thrombosis.
评估YAP血清水平对合并心血管疾病的类风湿关节炎患者（RA-CVD）实验室检查结果、影像学表现及疾病活动度的影响。
招募RA-CVD患者（n=60）、非心血管疾病的类风湿关节炎患者（RA-nCVD，n=60）和健康受试者（n=60）。采用qRT-PCR检测他们血清中的YAP水平。分析并比较他们的基线特征。评估并比较RA-CVD和RA-nCVD患者的疾病活动度、心血管疾病危险因素及影像学表现。此外，评估YAP对RA-CVD患者疾病活动度、心血管疾病危险因素及影像学表现的潜在影响。
与RA-nCVD患者相比，RA-CVD患者的红细胞沉降率（ERS）、抗环瓜氨酸肽抗体（anti-CCP）、类风湿因子（RF）、高密度脂蛋白胆固醇（HDL-C）、C反应蛋白（CRP）、Framingham心血管疾病风险评分（FRS）、脑钠肽（BNP）、左房内径（LA）、左室舒张末期内径（LVs）、左室收缩末期内径（LVd）及颈动脉内膜中层厚度（cIMT）水平较高，而射血分数（EF）水平较低。RA-CVD患者的YAP血清水平高于RA-nCVD患者和健康受试者。在RA-CVD患者中，YAP水平与疾病活动度评分28（DAS28）、甘油三酯（TG）、CRP、血小板计数（PLT）、FRS、BNP及cIMT呈正相关。
RA-CVD患者的YAP血清水平升高。YAP可能通过调节炎症反应、脂质代谢、糖代谢及血栓形成，推动类风湿关节炎患者心血管疾病的发展。
