International Atomic Energy Agency, Vienna, Austria.
The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Med Phys. 2024 Aug;51(8):5632-5644. doi: 10.1002/mp.17109. Epub 2024 May 3.
The TRS‑483, an IAEA/AAPM International Code of Practice on dosimetry of small static photon fields, underwent testing via an IAEA coordinated research project (CRP). Alongside small field output factors (OFs) measurements using active dosimeters by CRP participants, the IAEA Dosimetry Laboratory received a mandate to formulate a remote small field dosimetry audit method using its passive dosimetry systems.
This work aimed to develop a small field dosimetry audit methodology employing radiophotoluminescent dosimeters (RPLDs) and radiochromic films. The methodology was subsequently evaluated through a multicenter pilot study with CRP participants.
The developments included designing and manufacturing a dosimeter holder set and the characterization of an RPLD system for measurements in small photon fields using the new holder. The audit included verification of small field OFs and lateral beam profiles for small fields. At first, treatment planning system (TPS) calculated OFs were checked against a reference data set that was available for conventional linacs. Second, calculated OFs were verified through the RPLD measurement of point doses in a machine-specific reference field, 4 cm × 4 cm, 2 cm × 2 cm, and 1 cm × 1 cm, corresponding size circular fields or nearest achievable field sizes. Lastly, profile checks in in-plane and cross-plane directions were done for the two smallest fields by comparing film measurements with TPS calculations at 20%, 50%, and 80% isodose levels.
RPLD correction factors for small field measurements were approximately unity. However, they influenced the dose determination's overall uncertainty in small fields, estimated at 2.30% (k = 1 level). Considering the previous experience in auditing reference beam output following the TRS-398 Code of Practice, the acceptance limit of 5% for the ratio of the dose determined by RPLD to the dose calculated by TPS, D/D, was considered adequate. The multicenter pilot study included 15 participants from 14 countries (39 beams). Consistent with the previous findings, the results of the OF check against the reference data confirmed that TPSs tend to overestimate OFs for the smallest fields included in this exercise. All except three RPLD measurement results were within the acceptance limit, and the spread of results increased for smaller field sizes. The differences between the film measured and TPS calculated dose profiles were within 3 mm for most of the beams checked; deviated results revealed problems with TPS commissioning and calibration of the treatment unit collimation systems.
The newly developed small field dosimetry audit methodology proved effective and successfully complemented the CRP OF measurements by participants with RPLD audit results.
TRS-483 是国际原子能机构/亚太地区核不扩散与核安全组织(IAEA/AAPM)关于小静态光子场剂量学的国际实践规范,已通过一项 IAEA 协调研究项目(CRP)进行测试。除了 CRP 参与者使用主动剂量计进行小场输出因子(OFs)测量外,IAEA 剂量学实验室还受权制定一种使用其被动剂量计系统的远程小场剂量审计方法。
本工作旨在开发一种使用放射性光致发光剂量计(RPLD)和光致变色胶片的小场剂量审计方法。随后,通过 CRP 参与者的多中心试点研究对该方法进行了评估。
开发工作包括设计和制造剂量计支架套件,并对使用新支架在小光子场中测量的 RPLD 系统进行了表征。该审计包括对小场 OFs 和小场横向束流轮廓的验证。首先,通过与可用于常规直线加速器的参考数据集进行比较,检查治疗计划系统(TPS)计算的 OFs。其次,通过在机器特定参考场(4 cm×4 cm、2 cm×2 cm 和 1 cm×1 cm 对应大小的圆形场或最近可达到的场尺寸)中测量点剂量,通过 RPLD 测量验证计算的 OFs。最后,通过比较胶片测量值与 TPS 在 20%、50%和 80%等剂量水平处的计算值,在平面内和平面外方向对两个最小场进行了轮廓检查。
RPLD 用于小场测量的校正因子接近 1。然而,它们会影响小场中剂量测定的整体不确定性,估计为 2.30%(k=1 水平)。考虑到之前在根据 TRS-398 实践规范审核参考射束输出方面的经验,RPLD 测定的剂量与 TPS 计算的剂量之比(D/D)的接受限为 5%被认为是合适的。多中心试点研究包括来自 14 个国家的 15 名参与者(39 束)。与之前的发现一致,与参考数据的 OF 检查结果证实,TPS 倾向于高估本研究中包含的最小场的 OFs。除了三个 RPLD 测量结果外,所有结果均在接受限内,并且随着场尺寸的减小,结果的分布增加。在大多数经检查的射束中,胶片测量值与 TPS 计算出的剂量分布之间的差异在 3 mm 以内;偏离结果揭示了 TPS 调试和治疗单元准直系统校准方面的问题。
新开发的小场剂量审计方法被证明是有效的,并通过 RPLD 审计结果成功补充了 CRP 参与者的 OF 测量。