School of Anesthesiology, Weifang Medical University, Weifang 261053, China.
School of Anesthesiology, Weifang Medical University, Weifang 261053, China.
Biomed Pharmacother. 2024 Jun;175:116665. doi: 10.1016/j.biopha.2024.116665. Epub 2024 May 2.
Opioid receptor agonists are often used when cancer patients undergo surgery or analgesic treatment. As analgesics in clinical care, opioids can provide intraoperative or to chronic cancer pain relief. Immune function plays an important role in anti-cancer therapy, with cellular immunity, comprised principally of T-lymphocytes and natural killer cells, representing the primary anti-cancer immune response. However, it remains unclear whether immune function is further affected with the use of opioids in already immunocompromised cancer patients. This article provides a review of the effects of commonly used clinical opioids, including morphine, oxycodone, fentanyl and tramadol, on immune function in cancer patients. It provides a summary of current evidence regarding the immunomodulatory effects of opioids in the cancer setting and mechanisms underlying these interactions.
阿片受体激动剂常用于癌症患者接受手术或镇痛治疗时。作为临床护理中的镇痛药，阿片类药物可以提供术中或慢性癌症疼痛缓解。免疫功能在抗癌治疗中起着重要作用，细胞免疫主要由 T 淋巴细胞和自然杀伤细胞组成，是主要的抗癌免疫反应。然而，目前尚不清楚在已经免疫功能低下的癌症患者中使用阿片类药物是否会进一步影响免疫功能。本文综述了临床常用阿片类药物，包括吗啡、羟考酮、芬太尼和曲马多，对癌症患者免疫功能的影响。总结了目前关于阿片类药物在癌症环境中的免疫调节作用及其相互作用机制的证据。
