咖啡和咖啡因摄入与 COPD 风险的关联：基于 NHANES 2007-2012 的研究结果。
Association between coffee and caffeine intake and risk of COPD: Findings based on NHANES 2007-2012.
机构信息
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
出版信息
Heart Lung. 2024 Sep-Oct;67:53-61. doi: 10.1016/j.hrtlng.2024.04.015. Epub 2024 May 2.
BACKGROUND
The association between coffee and caffeine intake and the risk of COPD and lung function has not been thoroughly discussed in Americans, with subgroup and threshold effects remaining unclear.
OBJECTIVES
This study investigated the association between coffee and caffeine consumption and the risk of chronic obstructive pulmonary disease (COPD) as well as lung function utilizing data from the NHANES 2007-2012.
METHODS
We assessed the associations of coffee and caffeine consumption with the risk of COPD and lung function parameters, including FEV1 and FVC, adjusting for common demographic and disease characteristics in a cross-sectional analysis of NHANES data.
RESULTS
A total of 9763 participants were included in the study, and 592 were diagnosed with COPD. Multivariate regression models revealed positive associations between coffee and caffeine consumption and the risk of COPD and lung function. Subgroup analyses stratified by sex, DM, hypertension status, and smoking habits identified potential effect modifiers as well as inflection points from threshold effect examinations.
CONCLUSIONS
The results of this cross-sectional study indicated significant positive correlations between coffee and caffeine consumption and the risk of COPD. Additionally, positive correlations between exposure variables and FEV1 and FVC were detected. Among the stratification factors, smoking status exhibited the most potential for modifying effects. Future practices and research are needed to validate the results and explore the underlying mechanisms.
背景
咖啡和咖啡因摄入与 COPD 风险和肺功能之间的关系尚未在美国人群中得到充分探讨，亚组和阈值效应仍不清楚。
目的
本研究利用 NHANES 2007-2012 数据，探讨了咖啡和咖啡因摄入与慢性阻塞性肺疾病（COPD）风险以及肺功能（包括 FEV1 和 FVC）的关系。
方法
我们通过横断面分析 NHANES 数据，评估了咖啡和咖啡因摄入与 COPD 风险以及 FEV1 和 FVC 等肺功能参数之间的关系，同时调整了常见的人口统计学和疾病特征。
结果
本研究共纳入 9763 名参与者，其中 592 人被诊断为 COPD。多变量回归模型显示，咖啡和咖啡因摄入与 COPD 风险和肺功能呈正相关。按性别、糖尿病、高血压状态和吸烟习惯进行的亚组分析确定了潜在的效应修饰因子和阈值效应检查的拐点。
结论
这项横断面研究的结果表明，咖啡和咖啡因摄入与 COPD 风险之间存在显著的正相关关系。此外，还发现暴露变量与 FEV1 和 FVC 之间存在正相关关系。在分层因素中，吸烟状态显示出最强的潜在修饰效应。需要进一步的实践和研究来验证这些结果，并探讨潜在的机制。
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