肌动蛋白推开一个渗漏的管腔。

Actin pushes open a leaky lumen.

机构信息

Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China.

出版信息

Cell Stem Cell. 2024 May 2;31(5):587-588. doi: 10.1016/j.stem.2024.04.003.

DOI:10.1016/j.stem.2024.04.003

PMID:38701753

Abstract

Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al. establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.

摘要

利用基于人类干细胞的模型来理解人类上胚层在着床的最初阶段是如何形成的，Indana 等人确定了由顶端肌动蛋白聚合产生的推压力的作用，并揭示了在上胚层腔形态发生的背后存在一个两阶段的、受生物力学驱动的腔生长过程。