College of Marine Life Sciences, and Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.
Hunan Fisheries Science Institute, Changsha, 410153, China.
Fish Shellfish Immunol. 2024 Jun;149:109601. doi: 10.1016/j.fsi.2024.109601. Epub 2024 May 1.
Alternative splicing serves as a pivotal source of complexity in the transcriptome and proteome, selectively connecting various coding elements to generate a diverse array of mRNAs. This process encodes multiple proteins with either similar or distinct functions, contributing significantly to the intricacies of cellular processes. The role of alternative splicing in mammalian immunity has been well studied. Remarkably, the immune system of fish shares substantial similarities with that of humans, and alternative splicing also emerges as a key player in the immune processes of fish. In this review, we offer an overview of alternative splicing and its associated functions in the immune processes of fish, and summarize the research progress on alternative splicing in the fish immunity. Furthermore, we review the impact of alternative splicing on the fish immune system's response to external stimuli. Finally, we present our perspectives on future directions in this field. Our aim is to provide valuable insights for the future investigations into the role of alternative splicing in immunity.
选择性剪接是转录组和蛋白质组复杂性的关键来源，它选择性地连接各种编码元件，从而产生多样化的 mRNA。这个过程可以编码具有相似或不同功能的多种蛋白质，对细胞过程的复杂性有重要贡献。选择性剪接在哺乳动物免疫中的作用已经得到了很好的研究。值得注意的是，鱼类的免疫系统与人类有很大的相似之处，选择性剪接也成为鱼类免疫过程中的关键因素。在这篇综述中，我们概述了选择性剪接及其在鱼类免疫过程中的相关功能，并总结了鱼类免疫中选择性剪接的研究进展。此外，我们还回顾了选择性剪接对鱼类免疫系统对外界刺激反应的影响。最后，我们提出了对该领域未来发展方向的看法。我们的目的是为未来研究选择性剪接在免疫中的作用提供有价值的见解。
