Faculty of Innovation and Technology, School of Engineering, Chemical Engineering Programme, No.1 Jalan Taylor's, Taylor's University Malaysia, 47500 Subang Jaya, Selangor, Malaysia.
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Biomater Adv. 2024 Jul;161:213854. doi: 10.1016/j.bioadv.2024.213854. Epub 2024 Apr 16.
This review delves into the utilization of intermetallic alloys (IMAs) as advanced biomaterials for medical implants, scrutinizing their conceptual framework, fabrication challenges, and diverse manufacturing techniques such as casting, powder metallurgy, and additive manufacturing. Manufacturing techniques such as casting, powder metallurgy, additive manufacturing, and injection molding are discussed, with specific emphasis on achieving optimal grain sizes, surface roughness, and mechanical properties. Post-treatment methods aimed at refining surface quality, dimensional precision, and mechanical properties of IMAs are explored, including the use of heat treatments to enhance biocompatibility and corrosion resistance. The review presents an in-depth examination of IMAs-based implantable biomaterials, covering lab-scale developments and commercial-scale implants. Specific IMAs such as Nickel Titanium, Titanium Aluminides, Iron Aluminides, Magnesium-based IMAs, Zirconium-based IMAs, and High-entropy alloys (HEAs) are highlighted, with detailed discussions on their mechanical properties, including strength, elastic modulus, and corrosion resistance. Future directions are outlined, with an emphasis on the anticipated growth in the orthopedic devices market and the role of IMAs in meeting this demand. The potential of porous IMAs in orthopedics is explored, with emphasis on achieving optimal pore sizes and distributions for enhanced osseointegration. The review concludes by highlighting the ongoing need for research and development efforts in IMAs technologies, including advancements in design and fabrication techniques.
这篇综述深入探讨了金属间化合物（IMAs）作为医疗植入物的先进生物材料的应用，审视了它们的概念框架、制造挑战以及各种制造技术，如铸造、粉末冶金和增材制造。讨论了制造技术，如铸造、粉末冶金、增材制造和注塑成型，并特别强调了如何实现最佳晶粒尺寸、表面粗糙度和机械性能。还探讨了旨在改善 IMAs 表面质量、尺寸精度和机械性能的后处理方法，包括使用热处理来提高生物相容性和耐腐蚀性。本综述深入研究了基于 IMAs 的可植入生物材料，涵盖了实验室规模的开发和商业规模的植入物。重点介绍了特定的 IMAs，如镍钛、钛铝化物、铁铝化物、镁基 IMAs、锆基 IMAs 和高熵合金（HEAs），并详细讨论了它们的机械性能，包括强度、弹性模量和耐腐蚀性。概述了未来的发展方向，强调了骨科设备市场的预期增长以及 IMAs 在满足这一需求中的作用。探讨了多孔 IMAs 在骨科中的应用潜力，重点是实现最佳的孔径和分布，以增强骨整合。最后，强调了在 IMAs 技术方面需要进行研究和开发工作，包括在设计和制造技术方面的进展。
