College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China; Key Laboratory of Organ Development and Regeneration of Zhejiang Province, College of Life and Environmental Sciences, Hangzhou Normal University, 311121, Hangzhou, China.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China.
Chemosphere. 2024 Jun;358:142241. doi: 10.1016/j.chemosphere.2024.142241. Epub 2024 May 3.
Chlorothalonil (CTL), an organochloride fungicide applied for decades worldwide, has been found to be present in various matrixes and even accumulates in humans or other mammals through the food chain. Its high residue and diffusion in the environment have severely affected food security and public health. More and more research has considered CTL as a possible toxin to environmental non-target organisms, via influencing multiple systems such as metabolic, developmental, endocrine, genetic, and reproductive pathways. Aquatic organisms and amphibians are the most vulnerable species to CTL exposure, especially during the early period of development. Under experimental conditions, CTL can also have toxic effects on rodents and other non-target organisms. As for humans, CTL exposure is most often reported to be relevant to allergic reactions to the skin and eyes. We hope that this review will improve our understanding of the hazards and risks that CTL poses to non-target organisms and find a strategy for rational use.
百菌清（CTL）是一种有机氯类杀菌剂，已在全球范围内使用了数十年，现在已经在各种基质中被发现，甚至通过食物链在人类或其他哺乳动物体内积累。其在环境中的高残留和扩散严重影响了食品安全和公众健康。越来越多的研究认为 CTL 可能是一种对环境非靶标生物的毒素，通过影响代谢、发育、内分泌、遗传和生殖等多个系统。水生生物和两栖动物是最易受 CTL 暴露影响的物种，尤其是在发育的早期阶段。在实验条件下，CTL 对啮齿动物和其他非靶标生物也可能具有毒性作用。至于人类，CTL 暴露最常被报道与皮肤和眼睛过敏反应有关。我们希望这篇综述能提高我们对 CTL 对非靶标生物的危害和风险的认识，并找到合理使用的策略。
