Gottfried Schatz Research Center for Cell Signaling, Metabolism, and Aging, Division of Cell Biology, Histology, and Embryology, Medical University of Graz, Graz, Austria.
Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Trends Endocrinol Metab. 2024 Nov;35(11):981-995. doi: 10.1016/j.tem.2024.04.009. Epub 2024 May 4.
Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity identified in various metabolic derangements. During disease development, they locate to atherosclerotic plaques, adipose tissue (AT) of individuals with obesity, liver lesions in steatosis and steatohepatitis, and the intestinal lamina propria. LAMs can also emerge in the metabolically demanding microenvironment of certain tumors. In this review, we discuss major questions regarding LAM recruitment, differentiation, and self-renewal, and, ultimately, their acute and chronic functional impact on the development of metabolic diseases. Further studies need to clarify whether and under which circumstances LAMs drive disease progression or resolution and how their phenotype can be modulated to ameliorate metabolic disorders.
脂质相关巨噬细胞（LAMs）是具有脂质处理能力的吞噬细胞，在各种代谢紊乱中被发现。在疾病发展过程中，它们定位于动脉粥样硬化斑块、肥胖个体的脂肪组织（AT）、脂肪变性和脂肪性肝炎的肝病变，以及肠黏膜固有层。LAMs 也可以出现在某些肿瘤代谢需求高的微环境中。在这篇综述中，我们讨论了关于 LAM 募集、分化和自我更新的主要问题，以及它们对代谢性疾病发展的急性和慢性功能影响。进一步的研究需要阐明 LAMs 是否以及在何种情况下推动疾病进展或缓解，以及如何调节其表型以改善代谢紊乱。
