Wang Xuerui, Zou Yangbin, Zhang Ruxuan, Teng Chunyan, Ren Xuejiao, Zhang Haishan, Zhou Liting
Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China.
Front Physiol. 2022 Oct 11;13:984586. doi: 10.3389/fphys.2022.984586. eCollection 2022.
To clarify the relationship between colorectal serrated lesions and serum lipid levels, and provide a scientific basis for the identification and early clinical prevention and treatment of populations that are at risk for colorectal serrated lesions. Studies comparing serum lipid levels in patients with colorectal serrated lesions and controls were searched in PubMed, Embase, Web of Science, the Cochrane Library, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database. Relevant literature was screened according to the inclusion and exclusion criteria. The mean and standard deviation of the serum lipid levels in patients and controls were extracted from the included literature. The combined weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated using Review Manager 5.0 software to evaluate the relationship between serum lipid levels and colorectal serrated lesions. Publication bias of the included studies was evaluated by the Egger test. Twenty-three studies were included, comprising 2,063 patients and 63,909 controls. The serum high-density lipoprotein cholesterol (HDL-C) levels in the case group was significantly lower than in the control group (WMD = -0.122 mmol/L, 95% CI: 0.170-0.073). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum triglyceride levels in the case group were significantly higher than in the control group, and the WMDs were 0.180 mmol/L (95% CI: 0.061-0.299), 0.155 mmol/L (95% CI: 0.038-0.273), and 0.241 mmol/L (95% CI: 0.181-0.302), respectively. Colorectal serrated lesions may be related to blood lipid levels. Hyperlipidemia might be a risk factor for colorectal serrated lesions.
为阐明结直肠锯齿状病变与血脂水平之间的关系，为结直肠锯齿状病变高危人群的识别及早期临床防治提供科学依据。在PubMed、Embase、Web of Science、Cochrane图书馆、中国生物医学文献数据库、知网、万方数据库和维普数据库中检索比较结直肠锯齿状病变患者与对照组血脂水平的研究。根据纳入和排除标准筛选相关文献。从纳入文献中提取患者和对照组血脂水平的均值和标准差。使用Review Manager 5.0软件计算合并加权均数差（WMD）和95%置信区间（CI），以评估血脂水平与结直肠锯齿状病变之间的关系。采用Egger检验评估纳入研究的发表偏倚。共纳入23项研究，包括2063例患者和63909例对照。病例组血清高密度脂蛋白胆固醇（HDL-C）水平显著低于对照组（WMD=-0.122 mmol/L，95%CI：0.170-0.073）。病例组总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和血清甘油三酯水平显著高于对照组，WMD分别为0.180 mmol/L（95%CI：0.061-0.299）、0.155 mmol/L（95%CI：0.038-0.273）和0.241 mmol/L（95%CI：0.181-0.302）。结直肠锯齿状病变可能与血脂水平有关。高脂血症可能是结直肠锯齿状病变的一个危险因素。
