Mosier M A, Gottner M J
Department of Ophthalmology, University of California, Irvine 92717.
Metab Pediatr Syst Ophthalmol (1985). 1985;8(4):150-3.
The rationale for early identification of the stage of diabetic retinopathy immediately preceding development of fibrovascular proliferation is that early diagnosis affords the opportunity to treat by photocoagulation or other methods at the appropriate stage of retinal disease. Aids to identification include: venous abnormalities, intraretinal microvascular abnormalities, "cotton-wool" spots and fluorescein angiographic evidence of capillary non-perfusion. Although no one of these fundus changes is specific for the pre-proliferative stage of diabetic retinopathy, the presence of more than one of these findings increases the risk of subsequent fibrovascular proliferation. The development of frank proliferation frequently occurs within two years of first appearance of the preproliferative stage.
在纤维血管增殖发生之前尽早确定糖尿病视网膜病变阶段的基本原理是，早期诊断能为在视网膜疾病的适当阶段进行光凝或其他治疗方法提供机会。有助于诊断的迹象包括：静脉异常、视网膜内微血管异常、“棉絮状”斑以及毛细血管无灌注的荧光素血管造影证据。虽然这些眼底变化中没有一个对糖尿病视网膜病变的增殖前期具有特异性，但出现其中不止一项表现会增加随后发生纤维血管增殖的风险。明显增殖通常在增殖前期首次出现后的两年内发生。
