Anesthesia Operation Department, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Institute of Microbiology, Jiangxi Academy of Sciences, Nanchang, China.
Skin Pharmacol Physiol. 2024;37(1-3):19-31. doi: 10.1159/000539100. Epub 2024 May 6.
Disinfectants play a critical role in reducing healthcare-associated infections by eliminating microorganisms on surfaces. However, prolonged use of disinfectants may adversely affect the skin microflora, essential for skin health and infection prevention. This study investigates the impact of disinfection on the skin microbiota and metabolites of medical personnel in operating rooms, aiming to provide a scientific foundation for safeguarding their skin health.
We conducted 16S sequencing and metabolomic analysis to assess the effects of disinfection on the skin microbiota and metabolites of medical personnel. Samples were collected from operating room personnel after disinfectant exposure to identify changes in microbial communities and metabolite profiles.
Our analysis revealed that prolonged use of disinfectants led to alterations in skin microbial communities and microbial metabolites. These alterations included the production of harmful metabolites that could potentially promote skin infections and other health issues among medical personnel.
The findings underscore the importance of minimizing disruptions to skin microbiota and metabolites caused by long-term disinfectant use to preserve the overall health of medical personnel. This study provides valuable insights into the relationship between disinfectant use, skin microbiota, and metabolites, highlighting the necessity for further research in this area.
消毒剂在减少医疗机构相关感染方面发挥着关键作用，可消除表面的微生物。然而，消毒剂的长期使用可能会对皮肤微生物群产生不利影响，而皮肤微生物群对皮肤健康和感染预防至关重要。本研究旨在调查消毒对手术室医务人员皮肤微生物群和代谢物的影响，为保护其皮肤健康提供科学依据。
我们进行了 16S 测序和代谢组学分析，以评估消毒剂对医务人员皮肤微生物群和代谢物的影响。在接触消毒剂后，从手术室人员身上采集样本，以确定微生物群落和代谢物图谱的变化。
我们的分析表明，消毒剂的长期使用导致皮肤微生物群落和微生物代谢物发生改变。这些变化包括产生潜在有害的代谢物，这可能会促进医务人员的皮肤感染和其他健康问题。
研究结果强调了尽量减少长期使用消毒剂对皮肤微生物群和代谢物的干扰以维持医务人员整体健康的重要性。本研究深入探讨了消毒剂使用、皮肤微生物群和代谢物之间的关系，突出了该领域进一步研究的必要性。
