Borges Joyce Cordeiro, de Almeida Campos Luís André, Kretzschmar Elisângela Afonso Moura, Cavalcanti Isabella Macário Ferro
Federal University of Pernambuco (UFPE), Keizo Asami Institute (iLIKA), Recife, Pernambuco, Brazil.
Federal University of Paraiba (UFPB), Biotechnology Center (Cbiotec), João Pessoa, Paraiba, Brazil.
Int J Biol Macromol. 2024 Jun;269(Pt 1):132108. doi: 10.1016/j.ijbiomac.2024.132108. Epub 2024 May 6.
Natural and synthetic biodegradable polymers are widely used to obtain more sustainable films with biological, physicochemical, and mechanical properties for biomedical purposes. The incorporation of essential oils (EOs) in polymeric films can optimize the biological activities of these EOs, protect them from degradation, and serve as a prototype for new biotechnological products. This article aims to discuss updates over the last 10 years on incorporating EOs into natural and synthetic biodegradable polymer films for biomedical applications. Chitosan, alginates, cellulose, and proteins such as gelatine, silk, and zein are among the natural polymers most commonly used to prepare biodegradable films for release EOs. In addition to these, the most cited synthetic biodegradable polymers are poly(L-lactide) (PLA), poly(vinyl alcohol) (PVA), and poly(ε-caprolactone) (PCL). The EOs of clove, cinnamon, tea tree, eucalyptus, frankincense, lavender, thyme and oregano incorporated into polymeric films have been the most studied EOs in recent years in the biomedical field. Biomedical applications include antimicrobial activity against pathogenic bacteria and fungi, anticancer activity, potential for tissue engineering and regeneration with scaffolds and wound healing as dressings. Thus, this article reports on the importance of incorporating EOs into biodegradable polymer films, making these systems especially attractive for various biomedical applications.
天然和合成的可生物降解聚合物被广泛用于制备具有生物、物理化学和机械性能的更可持续的薄膜，以用于生物医学目的。在聚合物薄膜中加入精油（EOs）可以优化这些EOs的生物活性，保护它们不被降解，并作为新型生物技术产品的原型。本文旨在讨论过去10年中关于将EOs纳入用于生物医学应用的天然和合成可生物降解聚合物薄膜的最新进展。壳聚糖、藻酸盐、纤维素以及明胶、丝绸和玉米醇溶蛋白等蛋白质是最常用于制备用于释放EOs的可生物降解薄膜的天然聚合物。除此之外，最常被提及的合成可生物降解聚合物是聚（L-丙交酯）（PLA）、聚乙烯醇（PVA）和聚（ε-己内酯）（PCL）。近年来，在生物医学领域，纳入聚合物薄膜中的丁香、肉桂、茶树、桉树、乳香、薰衣草、百里香和牛至的EOs是研究最多的EOs。生物医学应用包括对致病细菌和真菌的抗菌活性、抗癌活性、使用支架进行组织工程和再生的潜力以及作为敷料的伤口愈合。因此，本文报道了将EOs纳入可生物降解聚合物薄膜的重要性，使这些系统对各种生物医学应用特别有吸引力。
