Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
School of Medicine, Nankai University, Tianjin, China.
CNS Neurosci Ther. 2024 May;30(5):e14720. doi: 10.1111/cns.14720.
Glioblastoma multiforme (GBM) is an aggressive malignant tumor with a high mortality rate and is the most prevalent primary intracranial tumor that remains incurable. The current standard treatment, which involves surgery along with concurrent radiotherapy and chemotherapy, only yields a survival time of 14-16 months. However, the introduction of tumor electric fields therapy (TEFT) has provided a glimmer of hope for patients with newly diagnosed and recurrent GBM, as it has been shown to extend the median survival time to 20 months. The combination of TEFT and other advanced therapies is a promising trend in the field of GBM, facilitated by advancements in medical technology.
In this review, we provide a concise overview of the mechanism and efficacy of TEFT. In addition, we mainly discussed the innovation of TEFT and our proposed blueprint for TEFT implementation.
Tumor electric fields therapy is an effective and highly promising treatment modality for GBM. The full therapeutic potential of TEFT can be exploited by combined with other innovative technologies and treatments.
多形性胶质母细胞瘤（GBM）是一种具有高死亡率的侵袭性恶性肿瘤，是最常见的无法治愈的原发性颅内肿瘤。目前的标准治疗方法是手术联合放化疗，仅能延长 14-16 个月的生存时间。然而，肿瘤电场治疗（TEFT）的引入为新诊断和复发性 GBM 患者带来了一线希望，因为它已被证明可将中位生存时间延长至 20 个月。随着医疗技术的进步，TEFT 与其他先进疗法的结合是 GBM 领域的一个有前途的趋势。
在本综述中，我们提供了 TEFT 的机制和疗效的简明概述。此外，我们主要讨论了 TEFT 的创新之处以及我们提出的 TEFT 实施蓝图。
肿瘤电场治疗是 GBM 的一种有效且极具前景的治疗方式。通过与其他创新技术和治疗方法相结合，可以充分发挥 TEFT 的治疗潜力。
