Department of Neurosurgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, China.
Department of Neurosurgery, the First Hospital of China Medical University, Shenyang, Liaoning, China.
CNS Neurosci Ther. 2023 Jul;29(7):1709-1720. doi: 10.1111/cns.14217. Epub 2023 Apr 23.
Glioma is the most common primary intracranial malignancy in clinical practice, and in particular, IDH-wildtype glioblastoma has the worst prognosis. In recent years, surgical resection combined with simultaneous radiotherapy and immune checkpoint inhibitors has made some progress, but the efficacy is still not satisfactory, which may be related to the low immunogenicity of glioma cells and the tumor immunosuppressive microenvironment.
A comprehensive review of relevant literature was conducted to explore the mechanisms by which tumors suppress antitumor immune responses and produce escape, with a focus on the immune cells in the tumor microenvironment (TME).
The mechanisms involved in immune evasion of glioma cells are complex and involve with immune cell differentiation and function.
Our review emphasizes the need for a more profound comprehension of the mechanisms involved in immune response and immune evasion in glioma, to formulate more efficacious treatment modalities.
在临床实践中，神经胶质瘤是最常见的原发性颅内恶性肿瘤，特别是 IDH 野生型胶质母细胞瘤的预后最差。近年来，手术切除联合同步放化疗和免疫检查点抑制剂治疗取得了一定进展，但疗效仍不理想，这可能与胶质瘤细胞的低免疫原性和肿瘤免疫抑制微环境有关。
对相关文献进行全面回顾，探讨肿瘤抑制抗肿瘤免疫反应并产生逃逸的机制，重点关注肿瘤微环境（TME）中的免疫细胞。
胶质瘤细胞免疫逃逸的机制复杂，涉及免疫细胞分化和功能。
我们的综述强调需要更深入地了解胶质瘤中免疫反应和免疫逃逸的机制，以制定更有效的治疗方案。
