Pachman L M, Friedman J M, Maryjowski-Sweeney M L, Jonnason O, Radvany R M, Sharp G C, Cobb M A, Battles N D, Crowe W E, Fink C W
Arthritis Rheum. 1985 Feb;28(2):151-7. doi: 10.1002/art.1780280208.
Ninety children with definite juvenile dermatomyositis (JDMS), who had been HLA typed, were tested for the presence of tissue or organ-specific antibodies. Sixty had active disease at the time of study. The mean disease duration was 4 years, and 30 had soft tissue calcifications. The following autoantibodies were sought: thyroid, gastric parietal cells, smooth muscle, striated muscle, microsomes, mitochondria, DNA, extractable nuclear antigen, Sm, PM-1, antinuclear antibody (ANA), and rheumatoid factor. Only the ANA and PM-1 were more frequent in patients than in controls (P less than 0.0002 and P less than 0.001, respectively). Higher levels of immune complexes (P less than 0.01) were found in sera from patients with JDMS than in sera from controls and were correlated with the presence of ANA in patients (P less than 0.01). Soft tissue calcification was not associated with any autoantibody or HLA antigen, but with disease duration and activity (P less than 0.001 and P less than 0.05, respectively). There was no association between the occurrence of any autoantibody and the presence of HLA-B8 or DR3 among the white patients with JDMS. The frequency of autoantibodies in 43 full siblings of children with JDMS was not increased. We conclude that children with JDMS, with or without HLA-B8/DR3, do not show evidence of a generalized nonspecific antibody response to tissue antigens. The significance of the increased antibody to nuclear antigens ANA and PM-1 remains to be determined.
对90名已进行HLA分型的确诊幼年皮肌炎（JDMS）患儿进行了组织或器官特异性抗体检测。60名患儿在研究时患有活动性疾病。平均病程为4年，30名患儿有软组织钙化。检测了以下自身抗体：甲状腺、胃壁细胞、平滑肌、横纹肌、微粒体、线粒体、DNA、可提取核抗原、Sm、PM - 1、抗核抗体（ANA）和类风湿因子。只有ANA和PM - 1在患者中的出现频率高于对照组（分别为P<0.0002和P<0.001）。与对照组相比，JDMS患者血清中免疫复合物水平更高（P<0.01），且与患者ANA的存在相关（P<0.01）。软组织钙化与任何自身抗体或HLA抗原均无关联，但与病程和疾病活动度相关（分别为P<0.001和P<0.05）。在患有JDMS的白人患者中，任何自身抗体的出现与HLA - B8或DR3的存在均无关联。43名JDMS患儿的同胞兄弟姐妹中自身抗体的出现频率并未增加。我们得出结论，无论有无HLA - B8/DR3，患有JDMS的儿童均未表现出对组织抗原的全身性非特异性抗体反应的证据。核抗原ANA和PM - 1抗体增加的意义尚待确定。
