Pilehvari Shamim, Gharakhani Bahar Tayebeh, Masoumi Seyedeh Zahra, Kazemi Farideh, Moradkhani Shirin, Rastgoo Haghi Alireza, Maleki Parvin
Endometrium and Endometriosis Research Center, Medicine School, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Midwifery, Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
J Family Reprod Health. 2023 Sep;17(3):142-150. doi: 10.18502/jfrh.v17i3.13537.
The purpose of this study is comparison of carob with placebo in the treatment of male infertility.
This study was performed as a clinical trial with two-group pretest-posttest design. Each group consisted of 30 members. The first group received 1.5 grams of carob per day, and the second group received placebo treatments. Treatment lasted for 12 weeks. Semen analysis as well as testosterone, prolactin, (LH), (FSH) and (TSH) were performed before and after drug treatment in two groups. Sexual function was assessed in the groups in two stages before and after the intervention using the standard International Index of Erectile Function. P-value less than 0.05 was considered statistically significant. Statistical analysis of data was performed using SPSS 16.
The participants' mean age was 34.83 ±6.22 in the placebo and 33.67 ±5.82 years in the Carob group. The results showed in the carob group compared to the placebo group, the rate of normal sperm counts increased by 17% and also the normal level of testosterone was 40% higher than the abnormal levels of the placebo group and these differences were statistically significant (P <0.05). And in most areas of sexual function, the mean scores after the intervention were higher than before (P> 0.05).
It is recommended to use carob supplements to improve spermogram parameters and male sex hormones.
本研究旨在比较角豆树与安慰剂治疗男性不育症的效果。
本研究采用两组前后测设计的临床试验。每组由30名成员组成。第一组每天服用1.5克角豆树，第二组接受安慰剂治疗。治疗持续12周。两组在药物治疗前后均进行了精液分析以及睾酮、催乳素、促黄体生成素（LH）、促卵泡生成素（FSH）和促甲状腺激素（TSH）的检测。使用标准国际勃起功能指数在干预前后两个阶段对两组的性功能进行评估。P值小于0.05被认为具有统计学意义。使用SPSS 16对数据进行统计分析。
安慰剂组参与者的平均年龄为34.83±6.22岁，角豆树组为33.67±5.82岁。结果显示，与安慰剂组相比，角豆树组正常精子计数率提高了17%，睾酮正常水平比安慰剂组异常水平高40%，这些差异具有统计学意义（P<0.05）。并且在性功能的大多数方面，干预后的平均得分高于干预前（P>0.05）。
建议使用角豆树补充剂来改善精液参数和男性性激素水平。
