Kamarehei Farideh, Noori Saleh Goran, Hemmati Jaber, Gohari Saeedeh
Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences Hamadan, Iran.
Department of Nursing, Tishk International University-Kurdistan Region Iraq.
Int J Clin Exp Pathol. 2024 Apr 15;17(4):96-107. doi: 10.62347/BVWH1940. eCollection 2024.
A nanoparticle-drug delivery system against , especially , has been recently proposed as an alternative pathway therapy. is resistance to many antibiotics, making it a a threat to human life, especially for older and immunocompromised people. Treatment of is considered an urgent need. A variety of kinds of nanoparticle-drug delivery systems with different compositions, and biological properties have been extensively investigated against . This review summarizes the novel nanoparticle-drug delivery systems against . These nanoparticle-drug delivery systems could reduce antibiotic resistance and minimize side effects of the antibiotics. Also, they can deliver a high concentration of the drugs and eliminate the bacteria in a specific and targeted site of infection. Despite these benefits of nanoparticle-drug delivery systems, the cytotoxicity, stress oxidative, genotoxicity, and inflammation that may occur and should not be ignored. Therefore, we need a better knowledge of the pharmacological properties and safety concerns of nanoparticle-drug delivery systems. The limitations of each nanoparticle-drug delivery system with high therapeutic potential have to be considered for further design.
一种针对[具体病原体名称未给出]，尤其是[另一种具体病原体名称未给出]的纳米颗粒药物递送系统，最近已被提议作为一种替代途径疗法。[病原体]对许多抗生素具有抗性，使其对人类生命构成威胁，尤其是对老年人和免疫功能低下的人。[病原体]的治疗被认为是一项迫切需求。针对[病原体]，已经广泛研究了具有不同组成和生物学特性的各种纳米颗粒药物递送系统。本综述总结了针对[病原体]的新型纳米颗粒药物递送系统。这些纳米颗粒药物递送系统可以降低抗生素抗性，并将抗生素的副作用降至最低。此外，它们可以递送高浓度的药物，并在特定的感染靶点消除细菌。尽管纳米颗粒药物递送系统有这些优点，但[病原体]感染时可能发生的细胞毒性、氧化应激、遗传毒性和炎症不应被忽视。因此，我们需要更好地了解纳米颗粒药物递送系统的药理学特性和安全性问题。在进一步设计时，必须考虑每种具有高治疗潜力的纳米颗粒药物递送系统的局限性。
