State Key Laboratory of NBC Protection for Civilian, Beijing, People's Republic of China.
Sichuan University of Science and Engineering, Zigong, People's Republic of China.
Sci Rep. 2024 May 8;14(1):10576. doi: 10.1038/s41598-024-61014-5.
Capsaicin derivatives with thiourea structure (CDTS) is highly noteworthy owing to its higher analgesic potency in rodent models and higher agonism in vitro. However, the direct synthesis of CDTS remains t one or more shortcomings. In this study, we present reported a green, facile, and practical synthetic method of capsaicin derivatives with thiourea structure is developed by using an automated synthetic system, leading to a series of capsaicin derivatives with various electronic properties and functionalities in good to excellent yields.
具有硫脲结构的辣椒素衍生物（CDTS）因其在啮齿动物模型中具有更高的镇痛效力和更高的体外激动作用而备受关注。然而，CDTS 的直接合成仍然存在一个或多个缺点。在本研究中，我们报道了一种使用自动化合成系统开发的具有硫脲结构的辣椒素衍生物的绿色、简便、实用的合成方法，该方法以良好至优异的收率得到了一系列具有各种电子性质和功能的辣椒素衍生物。
